Left ventricular recovery in an African cohort of patients with peripartum cardiomyopathy.

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  • Additional Information
    • Source:
      Publisher: African Field Epidemiology Network Country of Publication: Uganda NLM ID: 101517926 Publication Model: eCollection Cited Medium: Internet ISSN: 1937-8688 (Electronic) NLM ISO Abbreviation: Pan Afr Med J Subsets: MEDLINE
    • Publication Information:
      Original Publication: Kampala, Uganda : African Field Epidemiology Network
    • Subject Terms:
      Cardiomyopathies*/epidemiology ; Puerperal Disorders* ; Pregnancy Complications, Cardiovascular*; Pregnancy ; Female ; Humans ; Adult ; Cohort Studies ; Peripartum Period ; Heart Ventricles ; Ventricular Function, Left ; Stroke Volume
    • Abstract:
      Peripartum cardiomyopathy (PPCM) is a rare and potentially life-threatening disease associated with pregnancy. There are limited data regarding the outcome of PPCM and its predictive factors in sub-Saharan African patients. We prospectively conducted a double-center (cardiology unit of the department of medicine, Regional Hospital Center of Tenkodogo, Burkina Faso and the department of cardiology of the National Referral Teaching Hospital of N´Djamena, Chad) cohort study in patients with PPCM. Patients were consecutively enrolled from January 2015 to December 2017. Outcomes of interest were left ventricular recovery and poor outcome at one year. Ninety-four patients enrolled with a median age of 28 years. At one-year follow-up, 40.5% of them recovered their left ventricular function. Cox multiple regression analysis revealed that higher left ventricle ejection fraction (LVEF), lower natremia and use of betablockers were baseline variables predicting this end-point. Of the entire study population, 26.60% exhibited the composite end-point of death (n=15) or remaining in New York Heart Association (NYHA) class III-IV or LVEF < 35%. Predictors of poor outcome were lower LVEF at baseline, hyponatremia and use of digoxin. The current cohort study demonstrated that PPCM in sub-Saharan Africa is associated with limited myocardial recovery and significant rate of poor outcome at one year. Therefore, additional studies are needed to better address the disease.
      Competing Interests: The authors declare no competing interests.
      (Copyright: Dangwé Temoua Naïbé et al.)
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    • Contributed Indexing:
      Keywords: Africa; Peripartum cardiomyopathy; outcomes; recovery
    • Publication Date:
      Date Created: 20240219 Date Completed: 20240220 Latest Revision: 20240220
    • Publication Date:
      20240220
    • Accession Number:
      PMC10870155
    • Accession Number:
      10.11604/pamj.2024.47.6.42083
    • Accession Number:
      38371651