Skin lightening properties of zerumbone cream: A placebo-controlled study.

Publisher: Blackwell Science Country of Publication: England NLM ID: 101130964 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-2165 (Electronic) Linking ISSN: 14732130 NLM ISO Abbreviation: J Cosmet Dermatol Subsets: MEDLINE

Original Publication: Oxford, UK : Blackwell Science, c2002-

Skin Cream*/administration & dosage ; Skin Cream*/adverse effects ; Sesquiterpenes*/administration & dosage ; Sesquiterpenes*/adverse effects ; Sesquiterpenes*/pharmacology ; Skin Pigmentation*/drug effects ; Skin Lightening Preparations*/administration & dosage ; Skin Lightening Preparations*/adverse effects; Humans ; Adult ; Female ; Single-Blind Method ; Young Adult ; Male ; Melanins/analysis ; Administration, Cutaneous ; Erythema/chemically induced ; Erythema/prevention & control ; Middle Aged ; Forearm ; Skin/drug effects

Objective: Despite the demonstrated anti-melanogenic and UV protective effects of Zerumbone (ZER) in vitro, there is a lack of clinical trials that have been done to assess these properties. The primary objective of this study was to assess the effectiveness of ZER in lightening the skin tone of human participants with a single-blind approach.
Methods: Twenty-six participants were randomly assigned to two groups to investigate the application location (left or right volar forearm) for the placebo and ZER creams. Both creams were topically administered to the volar forearms twice daily over a duration of 4 weeks. Initial skin irritation was assessed before and 30 min after applying creams. The melanin and erythema levels were quantified with Mexameter MX 18.
Results: Twenty participants were included in the analysis. The cream formulation had excellent physical properties and was well-received by the participants. The initial skin irritation study results indicated that neither of the creams elicited an allergic reaction. The administration of ZER cream resulted in a statistically significant reduction in melanin levels (p < 0.05) after 1 week compared to the initial baseline. Furthermore, after 2 weeks of application, ZER cream demonstrated significant differences in melanin levels compared to placebo (p < 0.05). No adverse effects were observed in the group using ZER cream.
Conclusion: ZER demonstrated significant potential as a skin-lightening agent.
(© 2024 The Authors. Journal of Cosmetic Dermatology published by Wiley Periodicals LLC.)

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Taylor's University; FRGS/1/2019/SKK02/TAYLOR/03/2 Ministry of Higher Education (MOE) under Fundamental Research Grant Project; FRGS/1/2021/SKK0/MUSM/03/4 Ministry of Higher Education (MOE) under Fundamental Research Grant Project; My CytoHealth Sdn. Bhd.

Keywords: cream; formulation; skin lightening; zerumbone

0 (zerumbone)

Date Created: 20240217 Date Completed: 20240518 Latest Revision: 20240717

20240718

10.1111/jocd.16234

38366687