Bioinspired Injectable Polyurethane Underwater Adhesive with Fast Bonding and Hemostatic Properties.

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  • Additional Information
    • Source:
      Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE
    • Publication Information:
      Original Publication: Weinheim : WILEY-VCH, [2014]-
    • Subject Terms:
      Polyurethanes*/chemistry ; Adhesives*/chemistry ; Hemostatics*/chemistry ; Hemostatics*/pharmacology; Animals ; Materials Testing ; Wound Healing/drug effects ; Biocompatible Materials/chemistry ; Swine ; Tissue Adhesives/chemistry
    • Abstract:
      Underwater adhesives with injectable, organic solvent-free, strong, fast adhesion, and hemostatic properties have become an urgent need in biomedical field. Herein, a novel polyurethane underwater adhesive (PUWA) inspired by mussels is developed utilizing the rapid post-cure reaction of isocyanate esterification without organic solvents. The PUWA is created through the injectable two component curing process of component A (biocompatible polyurethane prepolymer) and component B (dopamine modified lysine derivatives: chain extender-LDA and crosslinker-L 3 DA). The two-component adhesive cures quickly and firmly underwater, with an impressive bonding strength of 40 kPa on pork skin and excellent burst pressure of 394 mmHg. Moreover, the PUWA exhibits robust adhesion strength in hostile environments with acid, alkali and saline solutions. Combined with excellent biocompatibility and hemostatic performance, the PUWA demonstrates effectively sealing wounds and promoting healing. With the ability to bond diverse substrates rapidly and strongly, the PUWA holds significant potential for application in both biomedical and industrial fields.
      (© 2024 The Authors. Advanced Science published by Wiley‐VCH GmbH.)
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    • Grant Information:
      U1930204 Key Program of National Natural Science Foundation of China; 51873117 National Natural Science Foundation of China; 2022NSFSC0375 Sichuan Science and Technology Program; MCMGD202304 Med-X Innovation Programme of Med-X center for Materials, Sichuan University; sklpme2022-2-07 State Key Laboratory of Polymer Materials Engineering
    • Contributed Indexing:
      Keywords: injectable; polyurethane; underwater adhesive; wound healing
    • Accession Number:
      0 (Polyurethanes)
      0 (Adhesives)
      0 (Hemostatics)
      0 (Biocompatible Materials)
      0 (Tissue Adhesives)
    • Publication Date:
      Date Created: 20240213 Date Completed: 20240424 Latest Revision: 20240426
    • Publication Date:
      20240426
    • Accession Number:
      PMC11040379
    • Accession Number:
      10.1002/advs.202308538
    • Accession Number:
      38350723