Aldehyde Reductase Activity of Carboxylic Acid Reductases.

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  • Additional Information
    • Source:
      Publisher: Wiley-VCH Verlag Country of Publication: Germany NLM ID: 100937360 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-7633 (Electronic) Linking ISSN: 14394227 NLM ISO Abbreviation: Chembiochem Subsets: MEDLINE
    • Publication Information:
      Original Publication: Weinheim, Germany : Wiley-VCH Verlag, c2000-
    • Subject Terms:
      Aldehyde Reductase* ; Oxidoreductases*; Aldehydes ; Carboxylic Acids
    • Abstract:
      Carboxylic acid reductase enzymes (CARs) are well known for the reduction of a wide range of carboxylic acids to the respective aldehydes. One of the essential CAR domains - the reductase domain (R-domain) - was recently shown to catalyze the standalone reduction of carbonyls, including aldehydes, which are typically considered to be the final product of carboxylic acid reduction by CAR. We discovered that the respective full-length CARs were equally able to reduce aldehydes. Herein we aimed to shed light on the impact of this activity on aldehyde production and acid reduction in general. Our data explains previously inexplicable results and a new CAR from Mycolicibacterium wolinskyi is presented.
      (© 2024 The Authors. ChemBioChem published by Wiley-VCH GmbH.)
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    • Grant Information:
      Government of Lower Austria and Vienna Business Agency in the framework of COMET - Competence Centers for Excellent Technologies; BMK; Standortagentur Tirol; SFG; 10.5577/6P33687 Austrian Science Fund (FWF); BMDW; I 4607 Austria FWF_ Austrian Science Fund FWF; 10.55776/I 4607 Austrian Science Fund (FWF)
    • Contributed Indexing:
      Keywords: 4 electron reduction; alcohol synthesis; aldehyde synthesis; carboxylic acid reductase; flavor and fragrance
    • Accession Number:
      EC 1.3.99.- (carboxylic acid reductase)
      EC 1.1.1.21 (Aldehyde Reductase)
      EC 1.- (Oxidoreductases)
      0 (Aldehydes)
      0 (Carboxylic Acids)
    • Publication Date:
      Date Created: 20240213 Date Completed: 20240418 Latest Revision: 20241127
    • Publication Date:
      20241202
    • Accession Number:
      10.1002/cbic.202400121
    • Accession Number:
      38349346