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Palmitic acid in type 2 diabetes mellitus promotes atherosclerotic plaque vulnerability via macrophage Dll4 signaling.
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- Author(s): Wang X;Wang X; Zhu L; Zhu L; Liu J; Liu J; Ma Y; Ma Y; Qiu C; Qiu C; Liu C; Liu C; Gong Y; Gong Y; Yuwen Y; Yuwen Y; Yuwen Y; Guan G; Guan G; Zhang Y; Zhang Y; Pan S; Pan S; Wang J; Wang J; Liu Z; Liu Z; Liu Z
- Source:
Nature communications [Nat Commun] 2024 Feb 12; Vol. 15 (1), pp. 1281. Date of Electronic Publication: 2024 Feb 12.- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
- Publication Information: Original Publication: [London] : Nature Pub. Group
- Subject Terms:
- Abstract: Patients with Type 2 Diabetes Mellitus are increasingly susceptible to atherosclerotic plaque vulnerability, leading to severe cardiovascular events. In this study, we demonstrate that elevated serum levels of palmitic acid, a type of saturated fatty acid, are significantly linked to this enhanced vulnerability in patients with Type 2 Diabetes Mellitus. Through a combination of human cohort studies and animal models, our research identifies a key mechanistic pathway: palmitic acid induces macrophage Delta-like ligand 4 signaling, which in turn triggers senescence in vascular smooth muscle cells. This process is critical for plaque instability due to reduced collagen synthesis and deposition. Importantly, our findings reveal that macrophage-specific knockout of Delta-like ligand 4 in atherosclerotic mice leads to reduced plaque burden and improved stability, highlighting the potential of targeting this pathway. These insights offer a promising direction for developing therapeutic strategies to mitigate cardiovascular risks in patients with Type 2 Diabetes Mellitus.
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2V16EO95H1 (Palmitic Acid)
0 (DLL4 protein, human)
0 (DLL4 protein, mouse) - Publication Date: Date Created: 20240212 Date Completed: 20240217 Latest Revision: 20240217
- Publication Date: 20240217
- Accession Number: PMC10861578
- Accession Number: 10.1038/s41467-024-45582-8
- Accession Number: 38346959
- Source:
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