Strong Diagnostic Performance of Single Energy 256-row Multidetector Computed Tomography with Deep Learning Image Reconstruction in the Assessment of Myocardial Fibrosis.

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  • Additional Information
    • Source:
      Publisher: Japanese Society of Internal Medicine Country of Publication: Japan NLM ID: 9204241 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1349-7235 (Electronic) Linking ISSN: 09182918 NLM ISO Abbreviation: Intern Med Subsets: MEDLINE
    • Publication Information:
      Original Publication: Tokyo, Japan : Japanese Society of Internal Medicine, [1992-
    • Subject Terms:
      Multidetector Computed Tomography*/methods ; Deep Learning* ; Fibrosis*/diagnostic imaging ; Cardiomyopathies*/diagnostic imaging ; Cardiomyopathies*/pathology ; Magnetic Resonance Imaging*/methods; Humans ; Male ; Female ; Middle Aged ; Aged ; Myocardium/pathology ; Image Processing, Computer-Assisted/methods ; Aged, 80 and over ; Retrospective Studies ; Adult ; Sensitivity and Specificity ; Heart Ventricles/diagnostic imaging ; Heart Ventricles/pathology
    • Abstract:
      Objective Although magnetic resonance imaging (MRI) is the gold standard for evaluating abnormal myocardial fibrosis and extracellular volume (ECV) of the left ventricular myocardium (LVM), a similar evaluation has recently become possible using computed tomography (CT). In this study, we investigated the diagnostic accuracy of a new 256-row multidetector CT with a low tube-voltage single energy scan and deep-learning-image reconstruction (DLIR) in detecting abnormal late enhancement (LE) in LVM. Methods We evaluated the diagnostic performance of CT for detecting LE in LVM and compared the results with those of MRI as a reference. We also measured the ECV of the LVM on CT and compared the results with those on MRI. Materials We analyzed 50 consecutive patients who underwent cardiac CT, including a late-phase scan and MRI, within three months of suspected cardiomyopathy. All patients underwent 256-slice CT (Revolution APEX; GE Healthcare, Waukesha, USA) with a low tube-voltage (70 kV) single energy scan and DLIR for a late-phase scan. Results In patient- and segment-based analyses, the sensitivity, specificity, and accuracy of detection of LE on CT were 94% and 85%, 100% and 95%, and 96% and 93%, respectively. The ECV of LVM per patient on CT and MRI was 33.0±6.2% and 35.9±6.1%, respectively. These findings were extremely strongly correlated, with a correlation coefficient of 0.87 (p<0.0001). The effective radiation dose on late-phase scanning was 2.4±0.9 mSv. Conclusion The diagnostic performance of 256-row multislice CT with a low tube voltage and DLIR for detecting LE and measuring ECV in LVM is credible.
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    • Contributed Indexing:
      Keywords: computed tomography; deep leaning image reconstruction; late enhancement; left ventricular myocardium
    • Publication Date:
      Date Created: 20240212 Date Completed: 20240916 Latest Revision: 20241018
    • Publication Date:
      20241018
    • Accession Number:
      PMC11473283
    • Accession Number:
      10.2169/internalmedicine.2615-23
    • Accession Number:
      38346744