Effect of platelet-activating factor on food intake, cloacal temperature, voluntary activity and crop emptying rate in chicks.

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  • Author(s): Tachibana T;Tachibana T; One C; One C; Khan S; Khan S; Khan S; Cline MA; Cline MA
  • Source:
    Prostaglandins & other lipid mediators [Prostaglandins Other Lipid Mediat] 2024 Jun; Vol. 172, pp. 106818. Date of Electronic Publication: 2024 Feb 08.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Elsevier Science Country of Publication: United States NLM ID: 9808648 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-8823 (Print) Linking ISSN: 10988823 NLM ISO Abbreviation: Prostaglandins Other Lipid Mediat Subsets: MEDLINE
    • Publication Information:
      Original Publication: New York : Elsevier Science, c1998-
    • Subject Terms:
      Body Temperature*/drug effects ; Chickens* ; Cloaca*/drug effects ; Cloaca*/physiology ; Crop, Avian*/drug effects ; Crop, Avian*/metabolism ; Eating*/drug effects ; Platelet Activating Factor*/pharmacology ; Platelet Activating Factor*/metabolism; Animals ; Male ; Feeding Behavior/drug effects ; Lipopolysaccharides/pharmacology ; Platelet Membrane Glycoproteins/genetics ; Platelet Membrane Glycoproteins/metabolism ; Receptors, G-Protein-Coupled/metabolism ; Receptors, G-Protein-Coupled/genetics
    • Abstract:
      Platelet-activating factor (PAF) plays a significant role in several leucocyte functions, including platelet aggregation and inflammation. Additionally, PAF has a role in the behavioral and physiological changes in mammals. However, the effect of PAF has not been well studied in birds. Therefore, the study aimed to determine if PAF affects feeding behavior, voluntary activity, cloacal temperature, and feed passage through the digestive tract in chicks (Gallus gallus). We also studied the involvement of PAF in the innate immune system induced by lipopolysaccharide (LPS), a cell wall component of gram-negative bacteria. Both intraperitoneal (IP) and intracerebroventricular (ICV) injections of PAF significantly decreased food intake. IP injection of PAF significantly decreased voluntary activity and slowed the feed passage from the crop, whereas ICV injection had no effect. Conversely, ICV injection of PAF significantly increased the cloacal temperature, but IP injection had no effect. The IP injection of LPS significantly reduced the mRNA expression of lysophosphatidylcholine acyltransferase 2, an enzyme responsible for PAF production in the heart and pancreas. On the other hand, LPS significantly increased the mRNA expression of the PAF receptor in the peripheral organs. The present study shows that PAF influences behavioral and physiological responses and is related to the response against bacterial infections in chicks.
      Competing Interests: Declaration of Competing Interest The authors declare that we have no competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
      (Copyright © 2024 Elsevier Inc. All rights reserved.)
    • Contributed Indexing:
      Keywords: Chick; Cloacal temperature, Crop emptying; Feeding; Lipopolysaccharide; Platelet-activating factor
    • Accession Number:
      0 (Lipopolysaccharides)
      0 (Platelet Activating Factor)
      0 (platelet activating factor receptor)
      0 (Platelet Membrane Glycoproteins)
      0 (Receptors, G-Protein-Coupled)
    • Publication Date:
      Date Created: 20240210 Date Completed: 20240509 Latest Revision: 20240610
    • Publication Date:
      20240610
    • Accession Number:
      10.1016/j.prostaglandins.2024.106818
    • Accession Number:
      38340978