Impaired sensitivity to thyroid hormones is associated with albuminuria in the euthyroid population: results from NHANES.

Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101142469 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2520-8721 (Electronic) Linking ISSN: 11093099 NLM ISO Abbreviation: Hormones (Athens) Subsets: MEDLINE

Publication: <2018-> : [Cham] : Springer International Publishing
Original Publication: Athens, Greece : Hellenic Endocrine Society, [2002]-

Albuminuria*/epidemiology ; Nutrition Surveys* ; Thyroid Hormones*/blood; Humans ; Female ; Male ; Cross-Sectional Studies ; Middle Aged ; Adult ; Thyroxine/blood ; Aged ; Thyrotropin/blood ; Triiodothyronine/blood

Purpose: The relationship between thyroid hormone sensitivity and albuminuria remains unclear. We aimed to investigate the association between thyroid hormone sensitivity and the risk of albuminuria in a euthyroid population.
Methods: This cross-sectional study included 7634 euthyroid adults collected from the National Health and Nutrition Examination Survey (NHANES) between 2007 and 2012. Central sensitivity to thyroid hormones was evaluated using the thyroid-stimulating hormone index (TSHI), the thyrotrophic thyroxine resistance index (TT4RI), and the thyroid feedback quantile-based index (TFQI). Peripheral sensitivity to thyroid hormones was measured using the free triiodothyronine/free thyroxine (FT3/FT4) ratio. Furthermore, the independent relationship between sensitivity to thyroid hormones and albuminuria was assessed.
Results: The proportion of albuminuria increased with a higher interquartile range of TFQI levels (7.31% vs. 7.89% vs. 7.95% vs. 9.89%, P = 0.024). Furthermore, TFQI was found to be independently associated with the risk of albuminuria after adjusting for confounding factors (OR = 1.28, 95% CI 1.01-1.60, P = 0.037). Subgroup analysis revealed a significant relationship between TFQI and albuminuria, especially among individuals over 60.
Conclusions: In euthyroid subjects, impaired central sensitivity to thyroid hormones is associated with albuminuria. TFQI holds significant potential as an epidemiological tool for quantifying the impact of impaired central sensitivity on the risk of albuminuria.
(© 2024. The Author(s), under exclusive licence to Hellenic Endocrine Society.)

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KRY-YN2022017 the Guang Ren Foundation Research Project of Affiliated Hospital of Jiangsu University; STL2021006 the Suzhou Science and Technology Planning Project

Keywords: Albuminuria; NHANES; Population-based study; Sensitivity to thyroid hormones; Thyroid feedback quantile-based index

0 (Thyroid Hormones)
Q51BO43MG4 (Thyroxine)
9002-71-5 (Thyrotropin)
06LU7C9H1V (Triiodothyronine)

Date Created: 20240210 Date Completed: 20240702 Latest Revision: 20240702

20240703

10.1007/s42000-024-00533-2

38340288