Effects of dried okra extract on lipid profile, renal function and some RAGE-related inflammatory genes expression in patients with diabetic nephropathy: A randomized controlled trial.

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  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: Scotland NLM ID: 9308777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6963 (Electronic) Linking ISSN: 09652299 NLM ISO Abbreviation: Complement Ther Med Subsets: MEDLINE
    • Publication Information:
      Publication: Edinburgh : Elsevier
      Original Publication: Edinburgh ; New York : Churchill Livingstone, c1993-
    • Subject Terms:
      Diabetic Nephropathies*/drug therapy ; Abelmoschus*/metabolism ; Diabetes Mellitus, Type 2*/metabolism; Humans ; Receptor for Advanced Glycation End Products/genetics ; Receptor for Advanced Glycation End Products/metabolism ; Receptor for Advanced Glycation End Products/therapeutic use ; Kidney/metabolism ; Lipids
    • Abstract:
      Background: Diabetic nephropathy (DN) is a common complication of type 2 diabetes. Okra (Abelmoschus esculentus L) is reported to have anti-diabetic effects. The present study aimed to investigate the effects of dried okra extract (DOE) supplementation on lipid profile, renal function indices, and expression of inflammatory genes, as well as serum level of soluble Receptor for Advanced glycation end products (sRAGE) in patients with DN.
      Methods: In this triple-blind randomized placebo-controlled clinical trial, 64 eligible patients with DN received either 125 mg of DOE or placebo daily along with DN-related nutritional recommendations for 10 weeks. Changes in kidney indices including proteinuria and estimated glomerular filtration rate (eGFR), lipid profile, serum SRAGE, as well as the expression of RAGE, ICAM-1, and IL-1 genes were measured over 10 weeks.
      Results: After adjustment for the potential confounders, between-group analyses showed no significant differences in terms of lipid profile, kidney function indices, sRAGE, and RAGE-related inflammatory genes expression after 10 weeks.
      Conclusion: Daily 125 mg DOE along with nutritional recommendations on top of usual care did not lead to significant changes in renal function indices, lipid profile, and inflammatory genes expression in patients with DN.
      Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
      (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
    • Contributed Indexing:
      Keywords: Diabetic nephropathy; Intercellular adhesion molecules; Interleukin 1 beta; Okra (Abelmoschus esculentus L); Receptor for advanced glycation end products; Soluble Receptor for advanced glycation end products
    • Accession Number:
      0 (Receptor for Advanced Glycation End Products)
      0 (Lipids)
    • Publication Date:
      Date Created: 20240209 Date Completed: 20240401 Latest Revision: 20240401
    • Publication Date:
      20240401
    • Accession Number:
      10.1016/j.ctim.2024.103027
    • Accession Number:
      38336011