Navigating Neurogenetics for Child and Adolescent Psychiatry Practice.

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  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: United States NLM ID: 8704565 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-5418 (Electronic) Linking ISSN: 08908567 NLM ISO Abbreviation: J Am Acad Child Adolesc Psychiatry Subsets: MEDLINE
    • Publication Information:
      Publication: Jan. 2010- : New York : Elsevier
      Original Publication: [Baltimore, Md.] : The Academy, [1987-
    • Subject Terms:
      Child Psychiatry* ; Adolescent Psychiatry* ; Neurodevelopmental Disorders*/genetics; Humans ; Child ; Adolescent ; Genetic Testing ; Developmental Disabilities/genetics ; Autism Spectrum Disorder/genetics ; Autism Spectrum Disorder/diagnosis ; DNA Copy Number Variations
    • Abstract:
      Neurodevelopmental disorders (NDDs) are a group of conditions characterized by impairments of brain processes that impact cognition, communication, motor abilities, and/or behavior during development. These conditions typically have significant effects across the life span and impact personal, social, academic, or occupational functioning. The US Centers for Disease Control and report that 1 in 6 children has a developmental disability, making it highly likely for child and adolescent psychiatrists to encounter children with NDDs in daily practice. 1 While the etiologies of NDDs are broad, genetic syndromes are a common cause of NDDs. The diagnostic yield of thorough genetic testing for NDDs as a group is about 40% based on meta-analysis, including 30% to 50% yield in patients with global developmental delay (GDD) or intellectual disability (ID) and 15% to 20% yield in patients with in autism spectrum disorder. 1-3 The findings are extremely heterogeneous, including chromosomal copy number variants (CNVs) and more than 2,000 known monogenic disorders associated with NDDs. 3 Diagnostic yields will increase over time with advances in technology and disease gene discovery. 3 .
      (Copyright © 2024 American Academy of Child and Adolescent Psychiatry. Published by Elsevier Inc. All rights reserved.)
    • Publication Date:
      Date Created: 20240207 Date Completed: 20240628 Latest Revision: 20240628
    • Publication Date:
      20240629
    • Accession Number:
      10.1016/j.jaac.2023.09.555
    • Accession Number:
      38325519