Interleukin-10 (−592 C/A) and interleukin-12B (+16974 A/C) gene polymorphisms and the interleukin-10 ATA haplotype are associated with periodontitis in a Taiwanese population.

Background and Objective: Single nucleotide polymorphisms are assumed to be associated with the differential production of cytokines. We evaluated gene polymorphisms of interleukin-10 (−592C>A, −819C>T and −1082G>A) and interleukin-12B (+16974) in patients with chronic periodontitis ( n = 145) and generalized aggressive periodontitis ( n = 65) in comparison with healthy controls ( n = 126). Material and Methods: Gene promoter polymorphisms were analyzed by polymerase chain reaction with sequence-specific primers. Genotype and allele frequencies were analyzed using the chi-square test and logistic regression analysis. Results: The interleukin-10 −592 polymorphism showed significant differences among the three groups ( p = 0.0330). The genotype frequencies of the −592 locus between the chronic periodontitis and healthy control groups were significantly different (AC vs. AA: odds ratio = 0.33). The combination ATA/ATA seemed to be associated with susceptibility to generalized aggressive periodontitis ( p = 0.0276). Patients with the composite ATA/ACC were less likely to develop chronic periodontitis ( p = 0.0248). The CC genotype of interleukin-12B (+16974) was related to chronic periodontitis (CC vs. AA, p = 0.0211; CC vs. AA+AC, p = 0.0187). The AC heterozygosity of interleukin-12B was significantly lower in chronic periodontitis vs. healthy controls ( p = 0.0500). Conclusion: The interleukin-10 gene polymorphism at position −592C>A may be associated with a lower risk for development of chronic periodontitis. The interleukin-10 haplotype ATA is associated with generalized aggressive periodontitis. On the other hand, interleukin-12B genetic variants at position +16974 are associated with susceptibility to chronic periodontitis. [ABSTRACT FROM AUTHOR]

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