Quantification of [ 99 Tc]TcO 4 - in urine by means of anion-exchange chromatography-aerosol desolvation nebulization-inductively coupled plasma-mass spectrometry.

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    • Source:
      Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 101134327 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-2650 (Electronic) Linking ISSN: 16182642 NLM ISO Abbreviation: Anal Bioanal Chem Subsets: MEDLINE
    • Publication Information:
      Original Publication: Heidelberg : Springer-Verlag, 2002-
    • Subject Terms:
      Chromatography*; Humans ; Mass Spectrometry/methods ; Spectrum Analysis ; Anions ; Indicators and Reagents
    • Abstract:
      To sensitively determine 99 Tc, a new method for internal quantification of its most common and stable species, [ 99 Tc]Tc O 4 - , was developed. Anion-exchange chromatography (IC) was coupled to inductively coupled plasma-mass spectrometry (ICP-MS) and equipped with an aerosol desolvation system to provide enhanced detection power. Due to a lack of commercial Tc standards, an isotope dilution-like approach using a Ru spike and called isobaric dilution analysis (IBDA) was used for internal quantification of 99 Tc. This approach required knowledge of the sensitivities of 99 Ru and 99 Tc in ICP-MS. The latter was determined using an in-house prepared standard manufactured from decayed medical 99m Tc-generator eluates. This standard was cleaned and preconcentrated using extraction chromatography with TEVA resin and quantified via total reflection X-ray fluorescence (TXRF) analysis. IC coupled to ICP-MS enabled to separate, detect and quantify [ 99 Tc]Tc O 4 - as most stable Tc species in complex environments, which was demonstrated in a proof of concept. We quantified this species in untreated and undiluted raw urine collected from a patient, who previously underwent scintigraphy with a 99m Tc-tracer, and determined a concentration of 19.6 ± 0.5 ng L -1 . The developed method has a high utility to characterize a range of Tc-based radiopharmaceuticals, to determine concentrations, purity, and degradation products in complex samples without the need to assess activity parameters of 99(m) Tc.
      (© 2024. The Author(s).)
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    • Grant Information:
      CRC 1450 - 431460824 Deutsche Forschungsgemeinschaft
    • Contributed Indexing:
      Keywords: Elemental speciation; Hyphenated ICP-MS techniques; On-line calibration; Pertechnetate; Trace analysis
    • Accession Number:
      0 (Anions)
      0 (Indicators and Reagents)
    • Publication Date:
      Date Created: 20240130 Date Completed: 20240415 Latest Revision: 20240729
    • Publication Date:
      20240729
    • Accession Number:
      PMC11009747
    • Accession Number:
      10.1007/s00216-024-05149-4
    • Accession Number:
      38289357