A novel score to predict left ventricular recovery in peripartum cardiomyopathy derived from the ESC EORP Peripartum Cardiomyopathy Registry.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Additional Information
    • Source:
      Publisher: Oxford University Press Country of Publication: England NLM ID: 8006263 Publication Model: Print Cited Medium: Internet ISSN: 1522-9645 (Electronic) Linking ISSN: 0195668X NLM ISO Abbreviation: Eur Heart J Subsets: MEDLINE
    • Publication Information:
      Publication: 2005- : Oxford : Oxford University Press
      Original Publication: London, Saunders [etc.]
    • Subject Terms:
      Cardiomyopathies*/diagnosis ; Puerperal Disorders* ; Heart Failure* ; Pregnancy Complications, Cardiovascular*; Pregnancy ; Female ; Humans ; Peripartum Period ; Ventricular Function, Left ; Stroke Volume
    • Abstract:
      Background and Aims: There are no established clinical tools to predict left ventricular (LV) recovery in women with peripartum cardiomyopathy (PPCM). Using data from women enrolled in the ESC EORP PPCM Registry, the aim was to derive a prognostic model to predict LV recovery at 6 months and develop the 'ESC EORP PPCM Recovery Score'-a tool for clinicians to estimate the probability of LV recovery.
      Methods: From 2012 to 2018, 752 women from 51 countries were enrolled. Eligibility included (i) a peripartum state, (ii) signs or symptoms of heart failure, (iii) LV ejection fraction (LVEF) ≤ 45%, and (iv) exclusion of alternative causes of heart failure. The model was derived using data from participants in the Registry and internally validated using bootstrap methods. The outcome was LV recovery (LVEF ≥50%) at six months. An integer score was created.
      Results: Overall, 465 women had a 6-month echocardiogram. LV recovery occurred in 216 (46.5%). The final model included baseline LVEF, baseline LV end diastolic diameter, human development index (a summary measure of a country's social and economic development), duration of symptoms, QRS duration and pre-eclampsia. The model was well-calibrated and had good discriminatory ability (C-statistic 0.79, 95% confidence interval [CI] 0.74-0.83). The model was internally validated (optimism-corrected C-statistic 0.78, 95% CI 0.73-0.82).
      Conclusions: A model which accurately predicts LV recovery at 6 months in women with PPCM was derived. The corresponding ESC EORP PPCM Recovery Score can be easily applied in clinical practice to predict the probability of LV recovery for an individual in order to guide tailored counselling and treatment.
      (© The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology.)
    • References:
      Obstet Gynecol. 2018 Feb;131(2):322-327. (PMID: 29324614)
      J Card Fail. 2011 May;17(5):426-30. (PMID: 21549301)
      Eur J Heart Fail. 2017 Dec;19(12):1712-1720. (PMID: 28597481)
      Int J Cardiol. 2024 Mar 1;398:131596. (PMID: 37979788)
      Circ Heart Fail. 2013 Sep 1;6(5):881-9. (PMID: 23888045)
      Eur Heart J. 2021 Sep 21;42(36):3599-3726. (PMID: 34447992)
      Clin Res Cardiol. 2017 Aug;106(8):582-589. (PMID: 28275862)
      J Card Fail. 2009 Oct;15(8):645-50. (PMID: 19786252)
      Eur Heart J. 2018 Sep 7;39(34):3165-3241. (PMID: 30165544)
      Int Heart J. 2019 May 30;60(3):503-511. (PMID: 31019181)
      Eur Heart J. 2020 Oct 14;41(39):3787-3797. (PMID: 32840318)
      Eur J Heart Fail. 2021 Dec;23(12):2058-2069. (PMID: 34114268)
      Eur J Heart Fail. 2014 May;16(5):583-91. (PMID: 24591060)
      Clin Res Cardiol. 2023 Mar;112(3):379-391. (PMID: 36131137)
      Hypertension. 2020 Jan;75(1):91-97. (PMID: 31707840)
      Basic Res Cardiol. 2013 Jul;108(4):366. (PMID: 23812247)
      Eur J Heart Fail. 2019 Jul;21(7):827-843. (PMID: 31243866)
      ESC Heart Fail. 2021 Apr;8(2):879-889. (PMID: 33453082)
      Eur Heart J. 2021 Aug 21;42(32):3094-3102. (PMID: 34322694)
      J Am Coll Cardiol. 2020 Nov 17;76(20):2352-2364. (PMID: 33183509)
      J Am Soc Echocardiogr. 2015 Jan;28(1):1-39.e14. (PMID: 25559473)
      JAMA Cardiol. 2020 Apr 1;5(4):432-441. (PMID: 31995119)
      N Engl J Med. 2001 May 24;344(21):1567-71. (PMID: 11372007)
      Eur J Heart Fail. 2018 Jun;20(6):951-962. (PMID: 29578284)
      J Am Coll Cardiol. 2015 Aug 25;66(8):905-14. (PMID: 26293760)
      Eur J Heart Fail. 2012 Aug;14(8):895-901. (PMID: 22588321)
      Int J Gynaecol Obstet. 2010 Apr;109(1):34-6. (PMID: 19945699)
      JACC Heart Fail. 2019 Sep;7(9):782-794. (PMID: 31401101)
    • Grant Information:
      FS/18/14/33330 United Kingdom BHF_ British Heart Foundation; 101045236 International ERC_ European Research Council
    • Contributed Indexing:
      Keywords: Left ventricular recovery; Peripartum cardiomyopathy; Prediction model
    • Publication Date:
      Date Created: 20240129 Date Completed: 20240422 Latest Revision: 20240426
    • Publication Date:
      20240426
    • Accession Number:
      PMC11032708
    • Accession Number:
      10.1093/eurheartj/ehad888
    • Accession Number:
      38282532