Screening, identifying, and treating chronic kidney disease: why, who, when, how, and what?

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  • Additional Information
    • Source:
      Publisher: BioMed Central Country of Publication: England NLM ID: 100967793 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2369 (Electronic) Linking ISSN: 14712369 NLM ISO Abbreviation: BMC Nephrol Subsets: MEDLINE
    • Publication Information:
      Original Publication: London : BioMed Central, [2000-
    • Subject Terms:
      Renal Insufficiency, Chronic*/diagnosis ; Renal Insufficiency, Chronic*/epidemiology ; Renal Insufficiency, Chronic*/therapy ; Hypertension*/drug therapy ; Diabetes Mellitus*/drug therapy; Adult ; Humans ; Middle Aged ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Kidney Function Tests ; Glomerular Filtration Rate
    • Abstract:
      1 in 7 American adults have chronic kidney disease (CKD); a disease that increases risk for CKD progression, cardiovascular events, and mortality. Currently, the US Preventative Services Task Force does not have a screening recommendation, though evidence suggests that screening can prevent progression and is cost-effective. Populations at risk for CKD, such as those with hypertension, diabetes, and age greater than 50 years should be targeted for screening. CKD is diagnosed and risk stratified with estimated glomerular filtration rate utilizing serum creatinine and measuring urine albumin-to-creatinine ratio. Once identified, CKD is staged according to C-G-A classification, and managed with lifestyle modification, interdisciplinary care and the recently expanding repertoire of pharmacotherapy which includes angiotensin converting enzyme inhibitors or angiotensin-II receptor blockers, sodium-glucose-cotransporter-2 inhibitors, and mineralocorticorticoid receptor antagonists. In this paper, we present the why, who, when, how, and what of CKD screening.
      (© 2024. The Author(s).)
    • References:
      Arch Intern Med. 2005 Apr 25;165(8):923-8. (PMID: 15851645)
      Am J Kidney Dis. 2020 Sep;76(3):446-449. (PMID: 32522576)
      Kidney Int. 2014 Jun;85(6):1303-9. (PMID: 24552851)
      J Am Soc Nephrol. 2007 Jun;18(6):1959-65. (PMID: 17475813)
      Am J Med. 2007 Dec;120(12):1063-70. (PMID: 18060927)
      Kidney Int. 2021 Jan;99(1):34-47. (PMID: 33127436)
      JAMA. 2001 Jul 25;286(4):421-6. (PMID: 11466120)
      JAMA. 2004 Feb 18;291(7):844-50. (PMID: 14970063)
      Am J Kidney Dis. 2014 May;63(5):713-35. (PMID: 24647050)
      N Engl J Med. 2014 Aug 28;371(9):796-7. (PMID: 25162885)
      Am J Med. 2011 Nov;124(11):1073-80.e2. (PMID: 22017785)
      Scand J Prim Health Care. 2001 Dec;19(4):247-8. (PMID: 11822649)
      JAMA Netw Open. 2021 Apr 1;4(4):e216139. (PMID: 33856475)
      J Am Soc Nephrol. 2009 Nov;20(11):2305-13. (PMID: 19833901)
      Lancet. 2016 Mar 5;387(10022):957-967. (PMID: 26724178)
      Am J Kidney Dis. 2022 Apr;79(4 Suppl 1):A8-A12. (PMID: 35331382)
      BMJ. 2013 Oct 03;347:f5680. (PMID: 24092942)
      JAMA Netw Open. 2020 Jul 1;3(7):e207932. (PMID: 32672828)
      N Engl J Med. 2005 Jul 21;353(3):238-48. (PMID: 16034009)
      N Engl J Med. 2009 Apr 2;360(14):1395-407. (PMID: 19332456)
      Cochrane Database Syst Rev. 2006 Oct 18;(4):CD006257. (PMID: 17054288)
      Lancet. 2010 Jun 12;375(9731):2073-81. (PMID: 20483451)
      Kidney Int. 2007 Jan;71(2):159-66. (PMID: 17136030)
      Eur Heart J. 2022 Feb 10;43(6):474-484. (PMID: 35023547)
      Pharmacol Res. 2013 Jun;72:35-44. (PMID: 23542730)
      N Engl J Med. 2016 Jul 28;375(4):323-34. (PMID: 27299675)
      J Am Soc Nephrol. 2006 Jul;17(7):2034-47. (PMID: 16738019)
      N Engl J Med. 2020 Oct 8;383(15):1436-1446. (PMID: 32970396)
      JAMA. 2003 Dec 17;290(23):3101-14. (PMID: 14679273)
      Diabetes Care. 2007 Jun;30(6):1577-8. (PMID: 17389334)
      Lancet Diabetes Endocrinol. 2019 Nov;7(11):845-854. (PMID: 31495651)
      N Engl J Med. 2004 Sep 23;351(13):1296-305. (PMID: 15385656)
      Diabetes Care. 2005 Sep;28(9):2106-12. (PMID: 16123474)
      N Engl J Med. 2021 Nov 4;385(19):1737-1749. (PMID: 34554658)
      Nephrol Dial Transplant. 2011 Sep;26(9):2827-47. (PMID: 21372254)
      Ann Pharmacother. 2007 Nov;41(11):1770-81. (PMID: 17925496)
      CMAJ. 2013 Aug 6;185(11):949-57. (PMID: 23798459)
      BMJ. 2008 Mar 22;336(7645):645-51. (PMID: 18299289)
      N Engl J Med. 1999 Sep 2;341(10):709-17. (PMID: 10471456)
      Am J Kidney Dis. 2020 Jan;75(1 Suppl 1):A6-A7. (PMID: 31704083)
      Nephrol Dial Transplant. 2008 Apr;23(4):1216-23. (PMID: 18359872)
      Am J Kidney Dis. 2015 Mar;65(3):354-66. (PMID: 25465166)
      Ann Pharmacother. 2013 Nov;47(11):1498-506. (PMID: 24259596)
      BMJ. 1993 Jun 26;306(6894):1722-5. (PMID: 8343628)
      Kidney Int. 2011 Jun;79(12):1341-52. (PMID: 21307840)
      N Engl J Med. 2017 Aug 17;377(7):644-657. (PMID: 28605608)
      Circulation. 2004 Jul 6;110(1):32-5. (PMID: 15210602)
      Lancet. 1982 Jan 16;1(8264):121-4. (PMID: 6119509)
      Int J Mol Sci. 2021 May 28;22(11):. (PMID: 34071680)
      BMC Nephrol. 2011 Jul 22;12:35. (PMID: 21777480)
      Clin Chem. 2009 Jan;55(1):24-38. (PMID: 19028824)
      N Engl J Med. 2001 Sep 20;345(12):870-8. (PMID: 11565519)
      Hypertension. 2021 Sep;78(4):1042-1052. (PMID: 34365812)
      Ann Pharmacother. 2007 Oct;41(10):1569-82. (PMID: 17712043)
      Diabetes Care. 2021 Sep;44(9):2000-2009. (PMID: 34233925)
      J Am Soc Nephrol. 1992 Oct;3(4 Suppl):S111-9. (PMID: 1457753)
      Circulation. 2018 Oct 23;138(17):e426-e483. (PMID: 30354655)
      N Engl J Med. 2023 Jan 12;388(2):117-127. (PMID: 36331190)
      N Engl J Med. 2019 Jun 13;380(24):2295-2306. (PMID: 30990260)
      J Appl Lab Med. 2023 Jul 5;8(4):789-816. (PMID: 37379065)
      Ann Intern Med. 2017 Sep 19;167(6):375-383. (PMID: 28869987)
      Diabetes Care. 2023 Jan 1;46(Suppl 1):S191-S202. (PMID: 36507634)
      N Engl J Med. 2015 Jun 18;372(25):2387-97. (PMID: 26039521)
      J Am Soc Nephrol. 2015 Aug;26(8):2055-64. (PMID: 25421558)
      Kidney Int. 2022 Nov;102(5):974-989. (PMID: 36202661)
      J Acad Nutr Diet. 2018 Oct;118(10):1958-1965. (PMID: 30076072)
      Clin Chem. 2023 Aug 2;69(8):777-784. (PMID: 37562009)
      Nephrol Dial Transplant. 1997;12 Suppl 2:6-9. (PMID: 9269691)
      Kidney Int Suppl. 2005 Apr;(94):S28-35. (PMID: 15752236)
      Ann Intern Med. 2014 Apr 15;160(8):550-7. (PMID: 24733196)
      Lancet. 1986 Dec 6;2(8519):1300-4. (PMID: 2878175)
      Kidney Int. 2011 Jun;79(12):1331-40. (PMID: 21289598)
      Am J Kidney Dis. 2010 Mar;55(3):463-73. (PMID: 20116910)
      Circulation. 2023 Dec 12;148(24):1982-2004. (PMID: 37947094)
      N Engl J Med. 2020 Dec 03;383(23):2219-2229. (PMID: 33264825)
      JAMA. 2016 Aug 9;316(6):602-10. (PMID: 27532915)
      Kidney Int. 2019 Nov;96(5):1048-1050. (PMID: 31582227)
      Clin Chem. 1988 Oct;34(10):2019-21. (PMID: 3168213)
      J Am Soc Nephrol. 2022 Sep;33(9):1767-1777. (PMID: 35853713)
      N Engl J Med. 2021 Dec 9;385(24):2252-2263. (PMID: 34449181)
      Lancet. 2011 Jun 25;377(9784):2181-92. (PMID: 21663949)
      Kidney Int. 2011 Jul;80(1):93-104. (PMID: 21289597)
      Hypertension. 2019 May;73(5):e35-e66. (PMID: 30827125)
      Clin J Am Soc Nephrol. 2015 May 7;10(5):732-9. (PMID: 25833405)
      N Engl J Med. 2009 Jan 8;360(2):129-39. (PMID: 19092145)
      Expert Rev Pharmacoecon Outcomes Res. 2008 Apr;8(2):165-78. (PMID: 20528406)
      Ann Intern Med. 1999 Nov 2;131(9):660-7. (PMID: 10577328)
      Drug Saf. 2006;29(11):1061-7. (PMID: 17061911)
      Am J Nephrol. 2018;48(6):447-455. (PMID: 30472707)
      Clin Chem. 2013 Apr;59(4):675-83. (PMID: 23315482)
      J Am Soc Nephrol. 2009 Feb;20(2):436-43. (PMID: 19092125)
      Am J Prev Med. 2017 Sep;53(3):300-307. (PMID: 28410862)
      Kidney Int. 1995 Jun;47(6):1703-20. (PMID: 7643540)
      Kidney Int. 2013 Sep;84(3):622-3. (PMID: 23989362)
      Ann Intern Med. 2023 Jun;176(6):788-797. (PMID: 37216661)
      Mayo Clin Proc Innov Qual Outcomes. 2023 Aug 29;7(5):382-391. (PMID: 37680649)
      PLoS One. 2020 Jan 21;15(1):e0227694. (PMID: 31961894)
      JAMA Intern Med. 2017 Oct 1;177(10):1498-1505. (PMID: 28873137)
      Kidney Int. 2006 Aug;70(3):536-42. (PMID: 16775595)
      Ann Intern Med. 2003 Aug 19;139(4):244-52. (PMID: 12965979)
      Ann Intern Med. 2001 Jul 17;135(2):73-87. (PMID: 11453706)
      Am J Kidney Dis. 2020 Sep;76(3 Suppl 1):S1-S107. (PMID: 32829751)
      Clin Chem. 2022 Mar 31;68(4):511-520. (PMID: 34918062)
      Hypertension. 2019 Jun;73(6):1275-1282. (PMID: 31067189)
      Kidney Int. 2021 Mar;99(3S):S1-S87. (PMID: 33637192)
      Med Clin North Am. 2005 May;89(3):457-73. (PMID: 15755462)
      J Am Soc Nephrol. 2020 Sep;31(9):1931-1940. (PMID: 32839279)
      N Engl J Med. 2008 Jun 12;358(24):2560-72. (PMID: 18539916)
      Circulation. 2003 Oct 28;108(17):2154-69. (PMID: 14581387)
      Am J Kidney Dis. 2012 Nov;60(5):713-5. (PMID: 23067638)
      Lancet. 1999 Feb 20;353(9153):617-22. (PMID: 10030326)
      Kidney Med. 2020 May 08;2(3):235-238. (PMID: 32734944)
      N Engl J Med. 2015 Nov 26;373(22):2103-16. (PMID: 26551272)
    • Contributed Indexing:
      Keywords: Albuminuria; CKD; Diabetes; Hypertension; Nephrology; Screening
    • Accession Number:
      0 (Angiotensin-Converting Enzyme Inhibitors)
    • Publication Date:
      Date Created: 20240125 Date Completed: 20240129 Latest Revision: 20241023
    • Publication Date:
      20241023
    • Accession Number:
      PMC10809507
    • Accession Number:
      10.1186/s12882-024-03466-5
    • Accession Number:
      38273240