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Plasma Concentration of 36 (Poly)phenols and Prospective Body Weight Change in Participants from the EPIC Cohort.
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- Additional Information
- Source:
Publisher: Karger Country of Publication: Switzerland NLM ID: 8105511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1421-9697 (Electronic) Linking ISSN: 02506807 NLM ISO Abbreviation: Ann Nutr Metab Subsets: MEDLINE
- Publication Information:
Original Publication: Basel ; New York : Karger, [1981-
- Subject Terms:
- Abstract:
Introduction: Dietary intake of (poly)phenols has been linked to reduced adiposity and body weight (BW) in several epidemiological studies. However, epidemiological evidence on (poly)phenol biomarkers, particularly plasma concentrations, is scarce. We aimed to investigate the associations between plasma (poly)phenols and prospective BW change in participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.
Methods: This study included 761 participants with data on BW at baseline and after 5 years of follow-up. Plasma concentrations of 36 (poly)phenols were measured at baseline using liquid chromatography-tandem mass spectrometry. Associations were assessed through general linear mixed models and multinomial logistic regression models, using change in BW as a continuous or as a categorical variable (BW loss, maintenance, gain), respectively. Plasma (poly)phenols were assessed as log2-transformed continuous variables. The false discovery rate (FDR) was used to control for multiple comparisons.
Results: Doubling plasma (poly)phenol concentrations showed a borderline trend towards a positive association with BW loss. Plasma vanillic acid showed the strongest association (-0.53 kg/5 years; 95% confidence interval [CI]: -0.99, -0.07). Similar results were observed for plasma naringenin comparing BW loss versus BW maintenance (odds ratio: 1.1; 95% CI: 1.0, 1.2). These results did not remain significant after FDR correction.
Conclusion: Higher concentrations of plasma (poly)phenols suggested a tendency towards 5-year BW maintenance or loss. While certain associations seemed promising, they did not withstand FDR correction, indicating the need for caution in interpreting these results. Further studies using (poly)phenol biomarkers are needed to confirm these suggestive protective trends.
(© 2024 The Author(s). Published by S. Karger AG, Basel.)
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- Grant Information:
001 International WHO_ World Health Organization; MC_UU_00006/3 United Kingdom MRC_ Medical Research Council
- Contributed Indexing:
Keywords: Body weight; Cohort; EPIC; Nutritional biomarker; Plasma (poly)phenol
- Accession Number:
0 (Phenols)
339NCG44TV (Phenol)
0 (Biomarkers)
- Publication Date:
Date Created: 20240125 Date Completed: 20240404 Latest Revision: 20240420
- Publication Date:
20240420
- Accession Number:
PMC10997261
- Accession Number:
10.1159/000535803
- Accession Number:
38272006
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