Mitral Annulus Calcium Score in Patients With Calcific Mitral Stenosis Undergoing Invasive Hemodynamic Assessment.

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  • Additional Information
    • Source:
      Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101580524 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2047-9980 (Electronic) Linking ISSN: 20479980 NLM ISO Abbreviation: J Am Heart Assoc Subsets: MEDLINE
    • Publication Information:
      Original Publication: Oxford : Wiley-Blackwell
    • Subject Terms:
      Mitral Valve Stenosis*/complications ; Atrial Fibrillation*/complications ; Heart Valve Diseases*/complications ; Aortic Valve Stenosis*/complications ; Aortic Valve Stenosis*/diagnostic imaging ; Aortic Valve Stenosis*/surgery ; Calcinosis*; Humans ; Female ; Middle Aged ; Aged ; Male ; Mitral Valve/diagnostic imaging ; Calcium ; Retrospective Studies ; Constriction, Pathologic ; Hemodynamics ; Cardiac Catheterization
    • Abstract:
      Background: Aortic valve calcium score is associated with hemodynamic severity of aortic stenosis. Whether this association is present in calcific mitral stenosis remains unknown.
      Methods and Results: This study was a retrospective analysis of consecutive patients with mitral stenosis secondary to mitral annular calcification (MAC) undergoing transseptal catheterization. All patients underwent invasive mitral valve assessment via direct left atrial and left ventricular pressure measurement. Computed tomography within 1 year of cardiac catheterization and with adequate visualization of the mitral annulus was included. MAC calcium score quantification by Agatston method was obtained offline using dedicated software (Aquarius, TeraRecon, V.4). Median patient age was 66.9±11.2 years, 47% of patients were women, 50% had coronary artery disease, 40% had atrial fibrillation, 47% had prior cardiac surgery, and 33% had prior chest radiation. Median diastolic mitral valve gradient was 9.4±3.4 mm Hg on echocardiography and 8.5±4 mm Hg invasively. Invasive median mitral valve area using the Gorlin formula was 1.87±0.9 cm 2 . Median MAC calcium score for the cohort was 7280±7937 Hounsfield units. MAC calcium score correlated with the presence of atrial fibrillation ( P =0.02) but was not associated with other comorbidities. There was no correlation between MAC calcium score and mitral valve area ( r =0.07; P =0.6) or mitral valve gradient ( r =-0.03; P =0.8).
      Conclusions: MAC calcium score did not correlate with invasively measured mitral valve gradient and mitral valve area in patients with MAC-related mitral stenosis, suggesting that calcium score should not be used as a surrogate for invasive hemodynamic parameters.
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    • Contributed Indexing:
      Keywords: calcium score; invasive hemodynamics; mitral annular calcification
    • Accession Number:
      SY7Q814VUP (Calcium)
    • Publication Date:
      Date Created: 20240119 Date Completed: 20240207 Latest Revision: 20240430
    • Publication Date:
      20240430
    • Accession Number:
      PMC11056119
    • Accession Number:
      10.1161/JAHA.123.030540
    • Accession Number:
      38240203