Antidiabetic and antioxidant potential of Crocin in high-fat diet plus streptozotocin-induced type-2 diabetic rats.

Publisher: Sage Publications Country of Publication: England NLM ID: 8911335 Publication Model: Print Cited Medium: Internet ISSN: 2058-7384 (Electronic) Linking ISSN: 03946320 NLM ISO Abbreviation: Int J Immunopathol Pharmacol Subsets: MEDLINE

Publication: 2015- : London : Sage Publications
Original Publication: [Chieti, Italy?] : Biomedical Research Press

Diabetes Mellitus, Experimental*/chemically induced ; Diabetes Mellitus, Experimental*/drug therapy ; Diabetes Mellitus, Type 2*/chemically induced ; Diabetes Mellitus, Type 2*/drug therapy ; Carotenoids*; Rats ; Animals ; Male ; Antioxidants/pharmacology ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Streptozocin ; Rats, Wistar ; Diet, High-Fat/adverse effects ; Insulin ; Glucose ; Body Weight ; Blood Glucose

Objectives: Crocin, the principal water-soluble active constituent of saffron, possesses numerous pharmacological activities. The present investigation examined the potential antidiabetic and antioxidant characteristics of Crocin in rats with type-2 diabetes by administering it orally and intraperitoneally (i.p.).
Methods: After 2 weeks of a high-fat diet, streptozotocin (STZ) (i.p., 40 mg/kg) was administered to male adult rats to induce type-2 diabetes mellitus. Body weight and fasting blood glucose (FBG) were measured on days zero, weeks 1, and 2. At the end of 2 weeks of drug administration in their respective groups, fasting insulin and glucose levels were estimated, and insulin resistance (HOMA-IR) was determined. Intraperitoneal glucose (IPGTT) and insulin tolerance tests (ITT) were carried out. Histopathological investigation and biochemical parameters were estimated in pancreatic tissues.
Results: The Crocin (100 mg/kg) treatment has significantly improved body weight, abatement of FBG, fasting insulin, and HOMA-IR. Likewise, Crocin treatment significantly improved the glucose and insulin challenges. We observed a significantly marked elevation in endogenous antioxidant enzymes in Crocin-treated groups. Similarly, Crocin treatment reversed the histopathological changes and restored the normal integrity and function of the pancreas.
Conclusion: The overall finding indicates that intraperitoneal administration of Crocin demonstrated better control of glycemic level and body weight. Further, it has improved insulin levels in the serum and potentiated antioxidant properties.
Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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Keywords: Crocin; antioxidants; insulin resistance; streptozotocin; type-2 diabetes mellitus

0 (Antioxidants)
0 (Hypoglycemic Agents)
877GWI46C2 (crocin)
5W494URQ81 (Streptozocin)
0 (Insulin)
IY9XDZ35W2 (Glucose)
0 (Blood Glucose)
36-88-4 (Carotenoids)

Date Created: 20240117 Date Completed: 20240119 Latest Revision: 20240121

20240121

PMC10798082

10.1177/03946320231220178

38233742