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Edible traditional Chinese medicines improve type 2 diabetes by modulating gut microbiotal metabolites.
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- Author(s): Chen S;Chen S;Chen S; Jiao Y; Jiao Y; Jiao Y; Han Y; Han Y; Han Y; Zhang J; Zhang J; Deng Y; Deng Y; Yu Z; Yu Z; Yu Z; Wang J; Wang J; He S; He S; Cai W; Cai W; Xu J; Xu J; Xu J; Xu J
- Source:
Acta diabetologica [Acta Diabetol] 2024 Apr; Vol. 61 (4), pp. 393-411. Date of Electronic Publication: 2024 Jan 16.- Publication Type:
Journal Article; Review- Language:
English - Source:
- Additional Information
- Source: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 9200299 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-5233 (Electronic) Linking ISSN: 09405429 NLM ISO Abbreviation: Acta Diabetol Subsets: MEDLINE
- Publication Information: Publication: Berlin : Springer Verlag
Original Publication: Berlin : Springer International, c1991- - Subject Terms:
- Abstract: Type 2 diabetes mellitus (T2DM) is a metabolic disorder with intricate pathogenic mechanisms. Despite the availability of various oral medications for controlling the condition, reports of poor glycemic control in type 2 diabetes persist, possibly involving unknown pathogenic mechanisms. In recent years, the gut microbiota have emerged as a highly promising target for T2DM treatment, with the metabolites produced by gut microbiota serving as crucial intermediaries connecting gut microbiota and strongly related to T2DM. Increasingly, traditional Chinese medicine is being considered to target the gut microbiota for T2DM treatment, and many of them are edible. In studies conducted on animal models, edible traditional Chinese medicine have been shown to primarily alter three significant gut microbiotal metabolites: short-chain fatty acids, bile acids, and branched-chain amino acids. These metabolites play crucial roles in alleviating T2DM by improving glucose metabolism and reducing inflammation. This review primarily summarizes twelve edible traditional Chinese medicines that improve T2DM by modulating the aforementioned three gut microbiotal metabolites, along with potential underlying molecular mechanisms, and also incorporation of edible traditional Chinese medicines into the diets of T2DM patients and combined use with probiotics for treating T2DM are discussed.
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- Contributed Indexing: Keywords: Bile acids; Branched-chain amino acids; Edible traditional Chinese medicines; Gut microbiotal metabolites; Short-chain fatty acids; T2DM
- Publication Date: Date Created: 20240116 Date Completed: 20240327 Latest Revision: 20240327
- Publication Date: 20240327
- Accession Number: 10.1007/s00592-023-02217-6
- Accession Number: 38227209
- Source:
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