Prevalence of viral hepatitis (A, B, C, and E) infection and co-infection among hospitalized children in Cairo, Egypt.

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  • Additional Information
    • Source:
      Publisher: Modern Commercial Press Country of Publication: Egypt NLM ID: 9816016 Publication Model: Print Cited Medium: Print ISSN: 1110-4902 (Print) NLM ISO Abbreviation: Egypt J Immunol Subsets: MEDLINE
    • Publication Information:
      Original Publication: Cairo : Modern Commercial Press,
    • Subject Terms:
      Coinfection*/epidemiology ; Hepatitis C*/diagnosis ; Hepatitis C*/epidemiology ; Hepatitis, Viral, Human*/epidemiology ; Hepatitis A virus* ; Hepatitis B*/epidemiology; Child ; Humans ; Infant ; Egypt/epidemiology ; Prevalence ; Cross-Sectional Studies ; Child, Hospitalized ; Hepatitis Viruses ; Hepacivirus/genetics ; Hepatitis B Surface Antigens ; Immunoglobulin M
    • Abstract:
      Viral hepatitis is considered a public health issue facing the entire world. The World Health Organization encouraged all countries to work together to eliminate this fatal infection and achieve the 2030 agenda. The present study aimed to investigate the silent infection of viral hepatitis (A, B, C, and E) among hospitalized children in Cairo, Egypt, to control and avoid chronic infection early on. This cross-sectional study included 184 randomly selected hospitalized children from three different hospitals in Cairo, Egypt. They were children aged between a few months to 15 years to determine viral hepatitis infection and co-infection. Antibodies to hepatitis A virus (HAV IgM), hepatitis E virus (HEV IgM), hepatitis C virus (HCV Ab), and hepatitis B virus surface antigen (HBs Ag) were performed by ELISA. If the ELISA results were positive, the viral load was quantified by real-time polymerase chain reaction (RT-PCR). Other laboratory investigations included alanine aminotransferase, aspartate aminotransferase, albumin, and complete blood count. Only five children (2.71%) had HCV Ab positive with no other viral (A, B, and E) co-infections as determined by ELISA. Also, the RT-PCR detected HCV RNA in these ELISA positive children. The remaining children (179/184) were all negative for all hepatitis viruses' markers (HAV IgM, HEV IgM, HBs Ag, and HCV Ab). In conclusion, this study documented that, Cairo hospitals serving Egyptian children had a low prevalence of viral hepatitis (A, B, C, and E). More research with larger sample sizes from hospitals across Egypt is needed.
      (Copyright© by the Egyptian Association of Immunologists.)
    • Accession Number:
      0 (Hepatitis B Surface Antigens)
      0 (Immunoglobulin M)
    • Publication Date:
      Date Created: 20240115 Date Completed: 20240116 Latest Revision: 20240116
    • Publication Date:
      20240116
    • Accession Number:
      38224033