The residue of salinomycin in the muscles of olive flounder (Paralichthys olivaceus) and black rockfish (Sebastes Schlegeli) after oral administration analyzed by LC-Tandem-MS.

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  • Additional Information
    • Source:
      Publisher: BioMed Central Country of Publication: England NLM ID: 101249759 Publication Model: Electronic Cited Medium: Internet ISSN: 1746-6148 (Electronic) Linking ISSN: 17466148 NLM ISO Abbreviation: BMC Vet Res Subsets: MEDLINE
    • Publication Information:
      Original Publication: London : BioMed Central, 2005-
    • Subject Terms:
    • Abstract:
      Background: Salinomycin, an antibiotic, have potential as a veterinary drug for fish due to its anti-parasitic activity against several fish parasites. Thus the residual levels of salinomycin in muscles of two significant aquaculture species in Korea, olive flounder and black rockfish, were analyzed using HPLC-MS-MS.
      Results: The proper method to analyze the residual salinomycin in fish muscles using LC-MS-MS was settled and the method was validated according to CODEX guidelines. The residues in three distinct groups for two fish species were analyzed using the matrix match calibration curves at points of five different times following oral administration. After oral administration, salinomycin rapidly breaks down in both olive flounder and black rockfish. After 7 th days, the average residue in all groups of two fish spp. decreased below limit of quantitation (LOQ).
      Conclusion: Due to low residue levels in fish muscles, salinomycin may therefore be a treatment that is safe for both fish and humans. This result could contribute to establishment of MRL (minimal residual limit) for approval of salinomycin for use in aquaculture.
      (© 2024. The Author(s).)
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    • Grant Information:
      NFQS2023002 Ministry of Oceans and Fisheries, Republic of Korea
    • Contributed Indexing:
      Keywords: Black rockfish; Olive flounder; Residue; Salinomycin; Veterinary drug
    • Accession Number:
      62UXS86T64 (salinomycin)
      0 (Polyether Polyketides)
      0 (Pyrans)
    • Publication Date:
      Date Created: 20240112 Date Completed: 20240115 Latest Revision: 20240115
    • Publication Date:
      20250114
    • Accession Number:
      PMC10785415
    • Accession Number:
      10.1186/s12917-023-03867-y
    • Accession Number:
      38216988