Changes in Isoleucine, Sarcosine, and Dimethylglycine During OGTT as Risk Factors for Diabetes.

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  • Additional Information
    • Source:
      Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375362 Publication Model: Print Cited Medium: Internet ISSN: 1945-7197 (Electronic) Linking ISSN: 0021972X NLM ISO Abbreviation: J Clin Endocrinol Metab Subsets: MEDLINE
    • Publication Information:
      Publication: 2017- : New York : Oxford University Press
      Original Publication: Springfield, Ill. : Charles C. Thomas
    • Subject Terms:
      Glucose Tolerance Test* ; Diabetes Mellitus, Type 2*/blood ; Diabetes Mellitus, Type 2*/epidemiology ; Diabetes Mellitus, Type 2*/metabolism ; Isoleucine*/blood ; Sarcosine*/analogs & derivatives ; Sarcosine*/blood ; Blood Glucose*/analysis ; Blood Glucose*/metabolism ; Glucose Intolerance*/blood ; Glucose Intolerance*/epidemiology ; Glucose Intolerance*/metabolism; Humans ; Male ; Female ; Middle Aged ; Risk Factors ; Adult ; Prediabetic State/blood ; Prediabetic State/epidemiology ; Prediabetic State/metabolism ; Metabolomics ; Aged ; Biomarkers/blood
    • Abstract:
      Context: Current metabolomics studies in diabetes have focused on the fasting state, while only a few have addressed the satiated state.
      Objective: We combined the oral glucose tolerance test (OGTT) and metabolomics to examine metabolite-level changes in populations with different glucose tolerance statuses and to evaluate the potential risk of these changes for diabetes.
      Methods: We grouped participants into those with normal glucose tolerance (NGT), impaired glucose regulation (IGR), and newly diagnosed type 2 diabetes (NDM). During the OGTT, serum was collected at 0, 30, 60, 120, and 180 minutes. We evaluated the changes in metabolite levels during the OGTT and compared metabolic profiles among the 3 groups. The relationship between metabolite levels during the OGTT and risk of diabetes and prediabetes was analyzed using a generalized estimating equation (GEE). The regression results were adjusted for sex, body mass index, fasting insulin levels, heart rate, smoking status, and blood pressure.
      Results: Glucose intake altered metabolic profile and induced an increase in glycolytic intermediates and a decrease in amino acids, glycerol, ketone bodies, and triglycerides. Isoleucine levels differed between the NGT and NDM groups and between the NGT and IGR groups. Changes in sarcosine levels during the OGTT in the diabetes groups were opposite to those in glycine levels. GEE analysis revealed that during OGTT, isoleucine, sarcosine, and acetic acid levels were associated with NDM risks, and isoleucine and acetate levels with IGR risks.
      Conclusion: Metabolic profiles differ after glucose induction in individuals with different glucose tolerance statuses. Changes in metabolite levels during OGTT are potential risk factors for diabetes development.
      (© The Author(s) 2024. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: [email protected].)
    • Grant Information:
      2022YFE0131400 National Key Research and Development Program of China
    • Contributed Indexing:
      Keywords: impaired glucose regulation; metabolomics; oral glucose tolerance test; type 2 diabetes
    • Accession Number:
      04Y7590D77 (Isoleucine)
      Z711V88R5F (Sarcosine)
      0 (Blood Glucose)
      7797M4CPPA (dimethylglycine)
      0 (Biomarkers)
    • Publication Date:
      Date Created: 20240112 Date Completed: 20240616 Latest Revision: 20240616
    • Publication Date:
      20240617
    • Accession Number:
      10.1210/clinem/dgae018
    • Accession Number:
      38214112