Turmeric Extract-loaded Selenium Nanoparticles Counter Doxorubicin-induced Hepatotoxicity in Mice via Repressing Oxidative Stress, Inflammatory Cytokines, and Cell Apoptosis.

Publisher: Bentham Science Publishers Country of Publication: Netherlands NLM ID: 101265649 Publication Model: Print Cited Medium: Internet ISSN: 1875-5992 (Electronic) Linking ISSN: 18715206 NLM ISO Abbreviation: Anticancer Agents Med Chem Subsets: MEDLINE

Publication: Amsterdam : Bentham Science Publishers
Original Publication: Sharjah, U.A.E. ; San Francisco, CA : Bentham Science Publishers, [2006]-

Doxorubicin*/pharmacology ; Oxidative Stress*/drug effects ; Selenium*/chemistry ; Selenium*/pharmacology ; Apoptosis*/drug effects ; Plant Extracts*/pharmacology ; Plant Extracts*/chemistry ; Cytokines*/metabolism ; Nanoparticles*/chemistry; Animals ; Mice ; Male ; Curcuma/chemistry ; Chemical and Drug Induced Liver Injury/drug therapy ; Chemical and Drug Induced Liver Injury/metabolism ; Chemical and Drug Induced Liver Injury/pathology ; Dose-Response Relationship, Drug ; Structure-Activity Relationship ; Antibiotics, Antineoplastic/pharmacology ; Cell Proliferation/drug effects

Background: Doxorubicin (DOX) is an antitumor anthracycline used to treat a variety of malignancies; however, its clinical use is associated with noticeable hepatotoxicity. Therefore, the current study was designed to delineate if biosynthesized SeNPs with turmeric extract (Tur-SeNPs) could alleviate DOX-induced hepatic adverse effects.
Methods: Mice were orally post-treated with Tur extract, Tur-SeNPs, or N-acetyl cysteine after the intraperitoneal injection of DOX.
Results: Our findings have unveiled a remarkable liver attenuating effect in DOX-injected mice post-treated with Tur-SeNPs. High serum levels of ALT, AST, ALP, and total bilirubin induced by DOX were significantly decreased by Tur-SeNPs therapy. Furthermore, Tur-SeNPs counteracted DOX-caused hepatic oxidative stress, indicated by decreased MDA and NO levels along with elevated levels of SOD, CAT, GPx, GR, GSH, and mRNA expression levels of Nrf-2. Noteworthily, decreased hepatic IL-1β, TNF-α, and NF-κB p65 levels in addition to downregulated iNOS gene expression in Tur-SeNPs-treated mice have indicated their potent antiinflammatory impact. Post-treatment with Tur-SeNPs also mitigated the hepatic apoptosis evoked by DOX injection. A liver histological examination confirmed the biochemical and molecular findings.
Conclusions: In brief, the outcomes have demonstrated Tur loaded with nanoselenium to successfully mitigate the liver damage induced by DOX via blocking oxidative stress, and inflammatory and apoptotic signaling.
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DSR-2021-03-03112 Deanship of Scientific Research at Jouf University

Keywords: Nanoselenium; apoptosis; doxorubicin; hepatotoxicity; oxidative stress.; turmeric extract

80168379AG (Doxorubicin)
H6241UJ22B (Selenium)
0 (Plant Extracts)
0 (Cytokines)
856YO1Z64F (turmeric extract)
0 (Antibiotics, Antineoplastic)

Date Created: 20240111 Date Completed: 20240528 Latest Revision: 20240528

20240528

10.2174/0118715206274530231213104519

38204261