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Gut Microbiome Composition and Dynamics in Hospitalized COVID-19 Patients and Patients with Post-Acute COVID-19 Syndrome.
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- Author(s): Brīvība M;Brīvība M; Silamiķele L; Silamiķele L; Birzniece L; Birzniece L; Ansone L; Ansone L; Megnis K; Megnis K; Silamiķelis I; Silamiķelis I; Pelcmane L; Pelcmane L; Borisova D; Borisova D; Rozenberga M; Rozenberga M; Jagare L; Jagare L; Elbere I; Elbere I; Kloviņš J; Kloviņš J
- Source:
International journal of molecular sciences [Int J Mol Sci] 2024 Jan 01; Vol. 25 (1). Date of Electronic Publication: 2024 Jan 01.- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
- Publication Information: Original Publication: Basel, Switzerland : MDPI, [2000-
- Subject Terms:
- Abstract: The gut microbiome plays a pivotal role in the modulation of host responses during viral infections, and recent studies have underscored its significance in the context of coronavirus disease 2019 (COVID-19). We aimed to investigate the dynamics and compositional changes in the gut microbiome of COVID-19 patients, addressing both the acute phase and the recovery process, with a particular focus on the emergence of post-COVID-19 conditions. Involving 146 COVID-19 patients and 110 healthy controls, this study employed a shotgun metagenomics approach for cross-sectional and longitudinal analyses with one- and three-month follow-ups. We observed a decline in taxonomic diversity among hospitalized COVID-19 patients compared to healthy controls, while a subsequent increase in alpha diversity was shown during the recovery process. A notable contribution of Enterococcus faecium was identified in the acute phase of the infection, accompanied by an increasing abundance of butyrate-producing bacteria (e.g., Roseburia , Lachnospiraceae_unclassified ) during the recovery period. We highlighted a protective role of the Prevotella genus in the long-term recovery process and suggested a potential significance of population-specificity in the early gut microbiome markers of post-acute COVID-19 syndrome. Our study represents distinctive gut microbiome signatures in COVID-19, with potential diagnostic and prognostic implications, pinpointing potential modulators of the disease progression.
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- Contributed Indexing: Keywords: COVID-19; gut microbiome; post-acute COVID-19 syndrome
- Publication Date: Date Created: 20240111 Date Completed: 20240112 Latest Revision: 20240113
- Publication Date: 20240113
- Accession Number: PMC10779053
- Accession Number: 10.3390/ijms25010567
- Accession Number: 38203738
- Source:
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