Biological Activity and Sterilization Mechanism of Marine Fungi-derived Aromatic Butenolide Asperbutenolide A Against Staphylococcus aureus.

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  • Additional Information
    • Source:
      Publisher: Verlag Helvetica Chimica Acta Country of Publication: Switzerland NLM ID: 101197449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1612-1880 (Electronic) Linking ISSN: 16121872 NLM ISO Abbreviation: Chem Biodivers Subsets: MEDLINE
    • Publication Information:
      Original Publication: Zürich, Switzerland : Hoboken, NJ : Verlag Helvetica Chimica Acta ; Distributed in the USA by Wiley, c2004-
    • Subject Terms:
      Methicillin-Resistant Staphylococcus aureus* ; Staphylococcal Infections*/drug therapy; 4-Butyrolactone/*analogs & derivatives; Staphylococcus aureus ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Microbial Sensitivity Tests ; Fungi ; RNA
    • Abstract:
      Marine fungi represent a huge untapped resource of natural products. The bio-activity of a new asperbutenolide A from marine fungus Aspergillus terreus was not well known. In the present study, the minimum inhibitory concentration (MIC) and RNA-Sequencing were used to analyze the bio-activity and sterilization mechanism of asperbutenolide A against clinical pathogenic microbes. The results showed that the MICs of asperbutenolide A against methicillin-resistant Staphylococcus aureus (MRSA) were 4.0-8.0 μg/mL. The asperbutenolide A present poor bio-activity against with candida. The sterilization mechanism of asperbutenolide A against MRSA showed that there were 1426 differentially-expressed genes (DEGs) between the groups of MRSA treated with asperbutenolide A and negative control. Gene Ontology (GO) classification analysis indicated that the DEGs were mainly involved in cellular process, metabolic process, cellular anatomical entity, binding, catalytic activity, etc. Kyoto Encyclopedia of Genes and Genomes (KEGG) classification analysis showed that these DEGs were mainly enriched in amino acid metabolism, carbohydrate metabolism, membrane transport, etc. Moreover, qRT-PCR showed similar trends in the expressions of argF, ureA, glmS and opuCA with the RNA-Sequencing. These results indicated that asperbutenolide A was with ideal bio-activity against with MRSA and could be as a new antibacterial agent.
      (© 2023 Wiley-VHCA AG, Zurich, Switzerland.)
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    • Grant Information:
      ZR2020QH272 Natural Science Foundation of Shandong Province; 2019YFF0216502 National Key Research and Development Project; 2021YXNS004 Research and Development Plan of Jining; 2022YXNS116 Research and Development Plan of Jining; 2022YXNS149 Research and Development Plan of Jining; 2022KJ096 Project of Shandong Province Higher Educational Youth Innovation Science and Technology Program; M-2023111 Shandong Traditional Chinese Medicine Technology Project; SDYWZGKCJHLH2023071 Shandong medical staff science and technology innovation plan project
    • Contributed Indexing:
      Keywords: RNA-Seq; asperbutenolide A; bio-acitve; clinical pathogenic microbes; sterilization mechanism
    • Accession Number:
      8KXK25H388 (butenolide)
      0 (Anti-Bacterial Agents)
      63231-63-0 (RNA)
      OL659KIY4X (4-Butyrolactone)
    • Publication Date:
      Date Created: 20231229 Date Completed: 20240222 Latest Revision: 20240222
    • Publication Date:
      20250114
    • Accession Number:
      10.1002/cbdv.202301826
    • Accession Number:
      38155523