Menu
×
West Ashley Library
9 a.m. - 7 p.m.
Phone: (843) 766-6635
Folly Beach Library
Closed
Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
Wando Mount Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. - 1 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. - 8 p.m.
Phone: (843) 889-3300
Otranto Road Library
9 a.m. - 8 p.m.
Phone: (843) 572-4094
Mt. Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 849-6161
McClellanville Library
9 a.m. - 6 p.m.
Phone: (843) 887-3699
Keith Summey North Charleston Library
9 a.m. - 8 p.m.
Phone: (843) 744-2489
John's Island Library
9 a.m. - 8 p.m.
Phone: (843) 559-1945
Hurd/St. Andrews Library
9 a.m. - 8 p.m.
Phone: (843) 766-2546
Miss Jane's Building (Edisto Library Temporary Location)
2 p.m. – 6 p.m.
Phone: (843) 869-2355
Dorchester Road Library
9 a.m. - 8 p.m.
Phone: (843) 552-6466
John L. Dart Library
9 a.m. - 7 p.m.
Phone: (843) 722-7550
Baxter-Patrick James Island
9 a.m. - 8 p.m.
Phone: (843) 795-6679
Main Library
9 a.m. - 8 p.m.
Phone: (843) 805-6930
Bees Ferry West Ashley Library
9 a.m. - 8 p.m.
Phone: (843) 805-6892
Mobile Library
9 a.m. - 5 p.m.
Phone: (843) 805-6909
Today's Hours
West Ashley Library
9 a.m. - 7 p.m.
Phone: (843) 766-6635
Folly Beach Library
Closed
Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
Wando Mount Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. - 1 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. - 8 p.m.
Phone: (843) 889-3300
Otranto Road Library
9 a.m. - 8 p.m.
Phone: (843) 572-4094
Mt. Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 849-6161
McClellanville Library
9 a.m. - 6 p.m.
Phone: (843) 887-3699
Keith Summey North Charleston Library
9 a.m. - 8 p.m.
Phone: (843) 744-2489
John's Island Library
9 a.m. - 8 p.m.
Phone: (843) 559-1945
Hurd/St. Andrews Library
9 a.m. - 8 p.m.
Phone: (843) 766-2546
Miss Jane's Building (Edisto Library Temporary Location)
2 p.m. – 6 p.m.
Phone: (843) 869-2355
Dorchester Road Library
9 a.m. - 8 p.m.
Phone: (843) 552-6466
John L. Dart Library
9 a.m. - 7 p.m.
Phone: (843) 722-7550
Baxter-Patrick James Island
9 a.m. - 8 p.m.
Phone: (843) 795-6679
Main Library
9 a.m. - 8 p.m.
Phone: (843) 805-6930
Bees Ferry West Ashley Library
9 a.m. - 8 p.m.
Phone: (843) 805-6892
Mobile Library
9 a.m. - 5 p.m.
Phone: (843) 805-6909
Patron Login
menu
Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
A high-fat and fructose diet in dogs mirrors insulin resistance and β-cell dysfunction characteristic of impaired glucose tolerance in humans.
Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
- Author(s): Gregory JM;Gregory JM; Kraft G; Kraft G; Dalla Man C; Dalla Man C; Slaughter JC; Slaughter JC; Scott MF; Scott MF; Hastings JR; Hastings JR; Edgerton DS; Edgerton DS; Moore MC; Moore MC; Cherrington AD; Cherrington AD
- Source:
PloS one [PLoS One] 2023 Dec 22; Vol. 18 (12), pp. e0296400. Date of Electronic Publication: 2023 Dec 22 (Print Publication: 2023).- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
- Publication Information: Original Publication: San Francisco, CA : Public Library of Science
- Subject Terms:
- Abstract: This study examined the impact of a hypercaloric high-fat high-fructose diet (HFFD) in dogs as a potential model for human impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM). The HFFD not only led to weight gain but also triggered metabolic alterations akin to the precursors of human T2DM, notably insulin resistance and β-cell dysfunction. Following the HFFD intervention, the dogs exhibited a 50% decrease in insulin sensitivity within the first four weeks, paralleling observations in the progression from normal to IGT in humans. Calculations of the insulinogenic index using both insulin and C-peptide measurements during oral glucose tolerance tests revealed a significant and sustained decrease in early-phase insulin release, with partial compensation in the later phase, predominantly stemming from reduced hepatic insulin clearance. In addition, the Disposition Index, representing the β-cell's capacity to compensate for diminished insulin sensitivity, fell dramatically. These results confirm that a HFFD can instigate metabolic changes in dogs akin to the early stages of progression to T2DM in humans. The study underscores the potential of using dogs subjected to a HFFD as a model organism for studying human IGT and T2DM.
Competing Interests: Justin Gregory has served as an advisory board member for Sanofi, Eli Lilly, Medtronic, Dompe, vTv Therapeutics, and Mannkind Corporation and in data and safety monitoring roles for vTv Therapeutics and Medtronic. Alan Cherrington is a scientific advisor, consultant, and holds stock in Fractyl Laboratories. He also holds stock in Metavention. The other authors have declared that no competing interests exist. This does not alter our adherence to PLOS ONE policies on sharing data and materials.
(Copyright: © 2023 Gregory et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.) - References: Diabetes Care. 2009 Feb;32(2):335-41. (PMID: 18957530)
Diabetes. 2001 Jan;50(1):150-8. (PMID: 11147781)
J Magn Reson Imaging. 2014 Feb;39(2):485-91. (PMID: 23596090)
Diabetes. 2006 May;55(5):1430-5. (PMID: 16644701)
Diabetes. 2004 Jun;53(6):1549-55. (PMID: 15161760)
Nutrients. 2019 Feb 19;11(2):. (PMID: 30791497)
Genome Res. 2005 Dec;15(12):1706-16. (PMID: 16339369)
Mol Metab. 2021 Nov;53:101281. (PMID: 34175474)
Diabetologia. 2021 Apr;64(4):914-922. (PMID: 33404681)
Diabetes. 2006 Apr;55(4):1074-9. (PMID: 16567531)
Diabet Med. 2000 Jun;17(6):433-40. (PMID: 10975211)
Diabetes. 2019 Sep;68(9):1709-1716. (PMID: 31431441)
Nat Rev Endocrinol. 2018 Mar;14(3):140-162. (PMID: 29348476)
Diabetes Care. 1997 Mar;20(3):396-404. (PMID: 9051394)
Diabetes Care. 2009 Mar;32(3):439-44. (PMID: 19056613)
Diabetes Care. 2006 May;29(5):1130-9. (PMID: 16644654)
Diabetes Care. 2003 Mar;26(3):868-74. (PMID: 12610051)
Science. 1966 Sep 2;153(3740):1127-8. (PMID: 5918576)
IEEE Trans Biomed Eng. 2002 May;49(5):419-29. (PMID: 12002173)
J Clin Invest. 1967 Mar;46(3):323-35. (PMID: 6023769)
Diabetol Metab Syndr. 2017 Oct 13;9:81. (PMID: 29046729)
Diabetes. 2005 Aug;54(8):2404-14. (PMID: 16046308)
Curr Diabetes Rev. 2014 Mar;10(2):131-45. (PMID: 24809394)
Lancet. 2009 Jun 27;373(9682):2215-21. (PMID: 19515410)
J Clin Invest. 1999 Sep;104(6):787-94. (PMID: 10491414)
Cells. 2022 Apr 27;11(9):. (PMID: 35563777)
Diabetes. 2001 Aug;50(8):1872-82. (PMID: 11473051)
Diabetologia. 1985 Jul;28(7):412-9. (PMID: 3899825)
Endocr Rev. 2018 Apr 1;39(2):79-132. (PMID: 29518206)
Br J Pharmacol. 2012 Jun;166(3):877-94. (PMID: 22352879)
Am J Physiol Endocrinol Metab. 2010 Dec;299(6):E887-98. (PMID: 20823448)
Diabetes. 1999 Nov;48(11):2197-203. (PMID: 10535454)
Diabetes Metab Res Rev. 2006 Mar-Apr;22(2):126-30. (PMID: 16187399)
Nat Rev Bioeng. 2023 May 11;:1-15. (PMID: 37359774)
Diabetes. 1992 Mar;41(3):368-77. (PMID: 1551497) - Grant Information: K23 DK123392 United States DK NIDDK NIH HHS; P30 DK020593 United States DK NIDDK NIH HHS; R01 DK018243 United States DK NIDDK NIH HHS
- Accession Number: 30237-26-4 (Fructose)
0 (Insulin)
0 (Blood Glucose) - Publication Date: Date Created: 20231222 Date Completed: 20231225 Latest Revision: 20240210
- Publication Date: 20240210
- Accession Number: PMC10745172
- Accession Number: 10.1371/journal.pone.0296400
- Accession Number: 38134122
- Source:
Contact CCPL
Copyright 2022 Charleston County Public Library Powered By EBSCO Stacks 3.3.0 [350.3] | Staff Login
No Comments.