Prognostic value of pretreatment indocyanine green angiography in the acute uveitic phase of Vogt-Koyanagi-Harada disease.

Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101468102 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1755-3768 (Electronic) Linking ISSN: 1755375X NLM ISO Abbreviation: Acta Ophthalmol Subsets: MEDLINE

Publication: Oxford, UK : Wiley-Blackwell
Original Publication: Oxford, UK ; Malden, MA : Blackwell Munksgaard

Uveomeningoencephalitic Syndrome*/diagnosis ; Uveomeningoencephalitic Syndrome*/complications ; Indocyanine Green*/administration & dosage ; Fluorescein Angiography*/methods ; Visual Acuity* ; Coloring Agents*/administration & dosage; Humans ; Male ; Female ; Retrospective Studies ; Adult ; Prognosis ; Acute Disease ; Middle Aged ; Young Adult ; Fundus Oculi ; Adolescent ; Aged ; Follow-Up Studies

Purpose: To investigate the prognostic value of pretreatment indocyanine green angiographic (ICGA) features in initial-onset acute uveitis associated with Vogt-Koyanagi-Harada (VKH) disease.
Methods: Retrospective analysis of 84 patients (168 eyes). Main outcome measures were final visual acuity, development of 'sunset glow fundus' (SGF) and progression to chronic recurrent evolution.
Results: Thirty-eight patients (76 eyes) presented in the phase preceding anterior segment (AS) inflammation (early presentation) and 46 patients (92 eyes) had AS inflammation at presentation (late presentation). The mean number of hypofluorescent dark dots (HDDs) and frequency of disc hyperfluorescence were more in the late presentation group (p < 0.001 for both comparisons), whereas the early presentation group showed higher frequencies of peripapillary punctate choroidal hyperfluorescence (p < 0.001) and hypofluorescent patches involving macula corresponding to the areas of exudative retinal detachment (p = 0.012). The mean number of HDDs and the frequency of disc hyperfluorescence were higher among eyes that developed SGF (p < 0.001 for both comparisons) and eyes that progressed to chronic recurrent evolution (p < 0.001; p = 0.001, respectively). The frequencies of peripapillary punctate choroidal hyperfluorescence and hypofluorescent patches corresponding to the areas of exudative retinal detachment were less in the eyes that developed SGF (p = 0.019; p = 0.003, respectively). Punctate choroidal hyperfluorescence elsewhere was less frequent in the eyes that developed SGF (p < 0.001) and eyes that progressed to chronic recurrent evolution (p = 0.002).
Conclusions: Pretreatment ICGA has a prognostic value in initial-onset acute uveitis associated with VKH disease.
(© 2023 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.)

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IFKSURC-1-2103 Deputyship for Research & Innovation, Ministry of Education in Saudi Arabia

Keywords: Vogt‐Koyanagi‐Harada disease; chronic recurrent evolution; indocyanine green angiography; prognosis; uveitis; ‘sunset glow fundus’

IX6J1063HV (Indocyanine Green)
0 (Coloring Agents)

Date Created: 20231222 Date Completed: 20240708 Latest Revision: 20240708

20240708

10.1111/aos.16613

38131519