CsA promotes trophoblast invasion accompanied by changes in leukaemic inhibitory factor and fibroblast growth factor in peri-implantation blastocysts.

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  • Additional Information
    • Source:
      Publisher: Cambridge University Press Country of Publication: England NLM ID: 9309124 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-8730 (Electronic) Linking ISSN: 09671994 NLM ISO Abbreviation: Zygote Subsets: MEDLINE
    • Publication Information:
      Original Publication: Cambridge ; New York, NY : Cambridge University Press, c1993-
    • Subject Terms:
      Fibroblast Growth Factors*/metabolism ; Trophoblasts*; Pregnancy ; Female ; Humans ; Blastocyst ; Embryo Implantation ; Endometrium/metabolism
    • Abstract:
      During the early stages of human pregnancy, successful implantation of embryonic trophoblast cells into the endometrium depends on good communication between trophoblast cells and the endometrium. Abnormal trophoblast cell function can cause embryo implantation failure. In this study, we added cyclosporine A (CsA) to the culture medium to observe the effect of CsA on embryonic trophoblast cells and the related mechanism. We observed that CsA promoted the migration and invasion of embryonic trophoblast cells. CsA promoted the expression of leukaemic inhibitory factor (LIF) and fibroblast growth factor (FGF). In addition, CsA promoted the secretion and volume increase in vesicles in the CsA-treated group compared with the control group. Therefore, CsA may promote the adhesion and invasion of trophoblast cells through LIF and FGF and promote the vesicle dynamic process, which is conducive to embryo implantation.
    • Contributed Indexing:
      Keywords: Cyclosporine A; Fibroblast growth factor; Invasion; Leukaemic inhibitory factor; Trophoblast
    • Accession Number:
      62031-54-3 (Fibroblast Growth Factors)
    • Publication Date:
      Date Created: 20231221 Date Completed: 20240116 Latest Revision: 20240116
    • Publication Date:
      20240116
    • Accession Number:
      10.1017/S0967199423000497
    • Accession Number:
      38124629