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Assessing early tubular protective effects of SGLT2 inhibitor empagliflozin against type 2 diabetes mellitus using functional magnetic resonance imaging.
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- Author(s): Zhang C;Zhang C; Zhu B; Zhu B; Feng Y; Feng Y; Cheng Z; Cheng Z; Cai X; Cai X; Feng L; Feng L; Li J; Li J; Lu X; Lu X
- Source:
Acta diabetologica [Acta Diabetol] 2024 Apr; Vol. 61 (4), pp. 473-483. Date of Electronic Publication: 2023 Dec 20.- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 9200299 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-5233 (Electronic) Linking ISSN: 09405429 NLM ISO Abbreviation: Acta Diabetol Subsets: MEDLINE
- Publication Information: Publication: Berlin : Springer Verlag
Original Publication: Berlin : Springer International, c1991- - Subject Terms:
- Abstract: Aims: To observe the alterations in functional magnetic resonance imaging parameters in normoalbuminuric type 2 diabetic patients undergoing SGLT2 inhibitor empagliflozin treatment and investigate the early tubular protective effects of the inhibitor.
Methods: This study was performed in normoalbuminuric type 2 diabetes mellitus patients (UACR < 30 mg/g, eGFR ≥ 60 ml/min/1.73 m 2 ). The patients were divided into the intervention group (empagliflozin) and the control group (27 cases each). The intervention group was treated with 10 mg/day empagliflozin tablets orally, while the control group had adjustments to their basic treatment stage. The patients were treated for 6 weeks.
Results: The baseline clinical data of the two groups were comparable (P˃0.05). The intervention group exhibited better improvements in blood lipid profiles and more significant reductions in blood uric acid levels compared to the control group (P < 0.05). The two groups had No significant difference in blood pressure changes (P˃0.05). Notably, the intervention group demonstrated a greater reduction in UACR and a more substantial decline in eGFR than the control group (P < 0.05). Regarding functional magnetic resonance imaging parameters, the MD value of the renal medulla region in the intervention group increased after treatment, while the MR2* value of the renal medulla region decreased (P < 0.05).
Conclusions: SGLT2 inhibitor empagliflozin can reduce UACR and eGFR levels in early type 2 diabetic patients with normal proteinuria. Moreover, empagliflozin therapy led to an increase in the MD value and a decrease in the MR2* value of the renal medulla, evidencing the early tubular protective effects of this therapy.
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Laursen JC et al. (2021) Acute effects of dapagliflozin on renal oxygenation and perfusion in type 1 diabetes with albuminuria: a randomised, double-blind, placebo-controlled crossover trial. eClinicalMedicine 37. - Contributed Indexing: Keywords: Functional magnetic resonance imaging; Lipids; SGLT2 inhibitor; Treatment; Type 2 diabetes
- Accession Number: 0 (Sodium-Glucose Transporter 2 Inhibitors)
HDC1R2M35U (empagliflozin)
0 (Benzhydryl Compounds)
0 (Glucosides) - Publication Date: Date Created: 20231220 Date Completed: 20240327 Latest Revision: 20240327
- Publication Date: 20240327
- Accession Number: 10.1007/s00592-023-02220-x
- Accession Number: 38117325
- Source:
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