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Epidemiology and burden of Severe Acute Respiratory Infections (SARI) in the aftermath of COVID-19 pandemic: A prospective sentinel surveillance study in a Tunisian Medical ICU, 2022/2023.
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- Author(s): Boussarsar M;Boussarsar M;Boussarsar M; Ennouri E; Ennouri E; Ennouri E; Habbachi N; Habbachi N; Bouguezzi N; Bouguezzi N; Bouguezzi N; Meddeb K; Meddeb K; Meddeb K; Gallas S; Gallas S; Gallas S; Hafdhi M; Hafdhi M; Zghidi M; Zghidi M; Zghidi M; Toumi R; Toumi R; Toumi R; Ben Saida I; Ben Saida I; Ben Saida I; Abid S; Abid S; Abid S; Boutiba-Ben Boubaker I; Boutiba-Ben Boubaker I; Boutiba-Ben Boubaker I; Maazaoui L; Maazaoui L; El Ghord H; El Ghord H; Gzara A; Gzara A; Yazidi R; Yazidi R; Yazidi R; Yazidi R; Ben Salah A; Ben Salah A; Ben Salah A
- Source:
PloS one [PLoS One] 2023 Dec 15; Vol. 18 (12), pp. e0294960. Date of Electronic Publication: 2023 Dec 15 (Print Publication: 2023).- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
- Publication Information: Original Publication: San Francisco, CA : Public Library of Science
- Subject Terms:
- Abstract: Background: Severe Acute Respiratory Infections (SARI) caused by influenza and other respiratory viruses pose significant global health challenges, and the COVID-19 pandemic has further strained healthcare systems. As the focus shifts from the pandemic to other respiratory infections, assessing the epidemiology and burden of SARI is crucial for healthcare planning and resource allocation. Aim: to understand the impact of the post-pandemic period on the epidemiology of SARI cases, clinical outcomes, and healthcare resource utilization in Tunisia.
Methods: This is a prospective study conducted in a Tunisian MICU part of a national sentinel surveillance system, focusing on enhanced SARI surveillance. SARI cases from week 39/2022, 26 September to week 19/2023, 13 May were included, according to a standardized case definition. Samples were collected for virological RT-PCR testing, and an electronic system ensured standardized and accurate data collection. Descriptive statistics were performed to assess epidemiology, trends, and outcomes of SARI cases, and univariate/multivariate analyses to assess factors associated with mortality.
Results: Among 312 MICU patients, 164 SARI cases were identified during the study period. 64(39%) RT-PCR were returned positive for at least one pathogen, with influenza A and B strains accounting for 20.7% of cases at the early stages of the influenza season. The MICU experienced a significant peak in admissions during weeks 1-11/2023, leading to resource mobilization and the creation of a surge unit. SARI cases utilized 1664/3120 of the MICU-stay days and required 1157 mechanical ventilation days. The overall mortality rate among SARI cases was 22.6%. Age, non-COPD, and ARDS were identified as independent predictors of mortality.
Conclusions: The present study identified a relatively high rate of SARI cases, with 39% positivity for at least one respiratory virus, with influenza A and B strains occurring predominantly during the early stages of the influenza season. The findings shed light on the considerable resource utilization and mortality associated with these infections, underscoring the urgency for proactive management and efficient resource allocation strategies.
Competing Interests: The authors have declared that no competing interests exist.
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- Publication Date: Date Created: 20231215 Date Completed: 20231218 Latest Revision: 20240131
- Publication Date: 20240131
- Accession Number: PMC10723666
- Accession Number: 10.1371/journal.pone.0294960
- Accession Number: 38100529
- Source:
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