Unraveling the role of collateral circulation and serum ELAVL1 in carotid atherosclerosis and ischemic stroke: Insights from clinical observations.

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  • Author(s): Song B;Song B; Chen X; Chen X; Pan K; Pan K; Chen X; Chen X
  • Source:
    Advances in clinical and experimental medicine : official organ Wroclaw Medical University [Adv Clin Exp Med] 2024 Sep; Vol. 33 (9), pp. 921-928.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Wroclaw Medical University Country of Publication: Poland NLM ID: 101138582 Publication Model: Print Cited Medium: Print ISSN: 1899-5276 (Print) Linking ISSN: 18995276 NLM ISO Abbreviation: Adv Clin Exp Med Subsets: MEDLINE
    • Publication Information:
      Original Publication: Wroclaw, Poland : Wroclaw Medical University
    • Subject Terms:
      Carotid Artery Diseases*/blood ; Carotid Artery Diseases*/physiopathology ; Carotid Artery Diseases*/diagnostic imaging ; Ischemic Stroke*/blood ; Ischemic Stroke*/physiopathology ; Ischemic Stroke*/diagnosis ; Ischemic Stroke*/etiology ; Collateral Circulation* ; ELAV-Like Protein 1*/blood; Humans ; Male ; Female ; Aged ; Middle Aged ; Prospective Studies ; Biomarkers/blood ; C-Reactive Protein/analysis ; C-Reactive Protein/metabolism
    • Abstract:
      Background: The (embryonic lethal, abnormal vision, drosophila)-like protein 1 (ELAVL1) is a newly discovered protein associated with cerebral ischemic/reperfusion (I/R) injury. However, little is known of ELAVL1 in ischemic stroke patients.
      Objectives: To investigate the clinical significance of collateral circulation and serum ELAVL1 in patients with carotid atherosclerosis (CAS) and ischemic stroke.
      Material and Methods: The present prospective cohort investigation included 317 ischemic stroke patients and 300 CAS patients admitted between March 2020 and March 2022. Collateral circulation was measured using digital subtraction angiography (DSA) and graded using the American Society of Interventional and Therapeutic Neuroradiology/Society of Interventional Radiology (ASITN/SIR) grading system. Enzyme-linked immunosorbent assays (ELISAs) were used to measure serum ELAVL1, C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-α). The serum levels of total cholesterol (TC), triglyceride (TG), high-density leptin cholesterol (HDL-C), and low-density leptin cholesterol (LDL-C) were also measured.
      Results: The serum levels of ELAVL1, CRP, IL-6, TNF-α, and LDL-C were all markedly higher, while HDL-C was significantly lower in ischemic stroke patients compared to the CAS patients. Serum ELAVL1 was markedly higher in ASITN/SIR grade 0-1 patients compared to grade 2-4 patients. Also, ELAVL1 correlated positively with serum CRP, IL-6, TNF-α, TC, and LDL-C, and negatively with HDL-C. Receiver operating characteristic (ROC) curves showed that ELAVL1 and collateral circulation have the potential to be used as biomarkers for the diagnosis of ischemic stroke. Meanwhile, CRP, IL-6, TNF-α, HDL-C, ASITN/SIR grading, and ELAVL1 were independent risk factors for ischemic stroke.
      Conclusions: We found that serum ELAVL1 was associated with clinical outcomes of ischemic stroke patients, while the combination of ELAVL1 and collateral circulation could be used as a potential biomarker for ischemic stroke diagnosis.
    • Contributed Indexing:
      Keywords: biomarker; carotid atherosclerosis; collateral circulation; ischemic stroke; observational study
    • Accession Number:
      0 (ELAV-Like Protein 1)
      0 (ELAVL1 protein, human)
      0 (Biomarkers)
      9007-41-4 (C-Reactive Protein)
    • Publication Date:
      Date Created: 20231208 Date Completed: 20240927 Latest Revision: 20241002
    • Publication Date:
      20241003
    • Accession Number:
      10.17219/acem/172700
    • Accession Number:
      38062655