Association between protein undernutrition and diabetes: Molecular implications in the reduction of insulin secretion.

Publisher: Springer Country of Publication: Germany NLM ID: 100940588 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2606 (Electronic) Linking ISSN: 13899155 NLM ISO Abbreviation: Rev Endocr Metab Disord Subsets: MEDLINE

Publication: 2005-: Heidelberg : Springer
Original Publication: Boston : Kluwer Academic Publishers, c2000-

Diabetes Mellitus* ; Nutrition Disorders* ; Malnutrition* ; Diabetes Mellitus, Type 2*; Humans ; Insulin Secretion ; Insulin/metabolism

Undernutrition is still a recurring nutritional problem in low and middle-income countries. It is directly associated with the social and economic sphere, but it can also negatively impact the health of the population. In this sense, it is believed that undernourished individuals may be more susceptible to the development of non-communicable diseases, such as diabetes mellitus, throughout life. This hypothesis was postulated and confirmed until today by several studies that demonstrate that experimental models submitted to protein undernutrition present alterations in glycemic homeostasis linked, in part, to the reduction of insulin secretion. Therefore, understanding the changes that lead to a reduction in the secretion of this hormone is essential to prevent the development of diabetes in undernourished individuals. This narrative review aims to describe the main molecular changes already characterized in pancreatic β cells that will contribute to the reduction of insulin secretion in protein undernutrition. So, it will provide new perspectives and targets for postulation and action of therapeutic strategies to improve glycemic homeostasis during this nutritional deficiency.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

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18/26080-4 Fundação de Amparo à Pesquisa do Estado de São Paulo; 2017/24851-0 Fundação de Amparo à Pesquisa do Estado de São Paulo

Keywords: Diabetes; Glucose homeostasis; Insulin secretion; Pancreatic β cells; Protein undernutrition

0 (Insulin)

Date Created: 20231204 Date Completed: 20240318 Latest Revision: 20241030

20241031

10.1007/s11154-023-09856-8

38048021