Changes of gut microbiota and short chain fatty acids in patients with Peutz-Jeghers syndrome.

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  • Additional Information
    • Source:
      Publisher: BioMed Central Country of Publication: England NLM ID: 100966981 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2180 (Electronic) Linking ISSN: 14712180 NLM ISO Abbreviation: BMC Microbiol Subsets: MEDLINE
    • Publication Information:
      Original Publication: London : BioMed Central, [2001-
    • Subject Terms:
      Peutz-Jeghers Syndrome*/genetics ; Peutz-Jeghers Syndrome*/pathology ; Gastrointestinal Microbiome*; Humans ; Germ-Line Mutation ; Fatty Acids, Volatile ; Butyrates
    • Abstract:
      Peutz-Jeghers Syndromeis a rare autosomal dominant genetic disease characterized by gastrointestinal hamartomatous polyps and skin and mucous membrane pigmentation. The pathogenesis of PJS remains unclear; however, it may be associated with mutations in the STK11 gene, and there is currently no effective treatment available. The gut microbiota plays an important role in maintaining intestinal homeostasis in the human body, and an increasing number of studies have reported a relationship between gut microbiota and human health and disease. However, relatively few studies have been conducted on the gut microbiota characteristics of patients with PJS. In this study, we analyzed the characteristics of the gut microbiota of 79 patients with PJS using 16 S sequencing and measured the levels of short-chain fatty acids in the intestines. The results showed dysbiosis in the gut microbiota of patients with PJS, and decreased synthesis of short-chain fatty acids. Bacteroides was positively correlated with maximum polyp length, while Agathobacter was negatively correlated with age of onset. In addition, acetic acid, propionic acid, and butyric acid were positively correlated with the age of onset but negatively correlated with the number of polyps. Furthermore, the butyric acid level was negatively correlated with the frequency of endoscopic surgeries. In contrast, we compared the gut microbiota of STK11-positive and STK11-negative patients with PJS for the first time, but 16 S sequencing analysis revealed no significant differences. Finally, we established a random forest prediction model based on the gut microbiota characteristics of patients to provide a basis for the targeted diagnosis and treatment of PJS in the future.
      (© 2023. The Author(s).)
    • References:
      J Clin Med. 2021 Jan 27;10(3):. (PMID: 33513864)
      FEMS Microbiol Lett. 2009 Oct;299(2):128-34. (PMID: 19732152)
      J Med Genet. 1997 Dec;34(12):1007-11. (PMID: 9429144)
      Cell Mol Life Sci. 2006 Sep;63(18):2135-44. (PMID: 16952058)
      J Med Invest. 2016;63(1-2):27-37. (PMID: 27040049)
      Front Psychiatry. 2020 Jul 10;11:664. (PMID: 32754068)
      J Dig Dis. 2023 Mar;24(3):203-212. (PMID: 37158702)
      Cancer Genet. 2019 Jan;230:47-57. (PMID: 30528796)
      Environ Microbiol. 2017 Jan;19(1):29-41. (PMID: 27928878)
      BMC Microbiol. 2020 Mar 11;20(1):56. (PMID: 32160858)
      Nat Commun. 2015 Mar 11;6:6528. (PMID: 25758642)
      N Engl J Med. 2019 Jan 31;380(5):472. (PMID: 30699321)
      Front Microbiol. 2022 Jul 13;13:881508. (PMID: 35910641)
      Dig Dis Sci. 2007 Aug;52(8):1924-33. (PMID: 17404884)
      Cell Mol Life Sci. 1999 May;55(5):735-50. (PMID: 10379360)
      Hum Mutat. 2005 Dec;26(6):513-9. (PMID: 16287113)
      Int J Clin Pract. 2017 Dec;71(12):. (PMID: 29168285)
      Gastroenterology. 2014 Nov;147(5):990-1007.e3. (PMID: 25058236)
      Bioinformatics. 2011 Nov 1;27(21):2957-63. (PMID: 21903629)
      J Gastroenterol. 1995 Nov;30 Suppl 8:45-7. (PMID: 8563888)
      Microbiol Spectr. 2017 Jun;5(3):. (PMID: 28643627)
      Best Pract Res Clin Gastroenterol. 2022 Jun-Aug;58-59:101789. (PMID: 35988959)
      Cell Host Microbe. 2021 Oct 13;29(10):1589-1598.e6. (PMID: 34536346)
      Nat Rev Genet. 2017 Nov;18(11):690-699. (PMID: 28824167)
      J Med Genet. 2004 May;41(5):327-33. (PMID: 15121768)
      Genome Biol. 2011 Jun 24;12(6):R60. (PMID: 21702898)
      Curr Opin Gastroenterol. 2021 May 1;37(3):245-254. (PMID: 33591027)
      Gut Microbes. 2021 Jan-Dec;13(1):1-21. (PMID: 33525961)
      Nat Methods. 2013 Jan;10(1):57-9. (PMID: 23202435)
      Science. 2018 Feb 2;359(6375):592-597. (PMID: 29420293)
      Biochim Biophys Acta Rev Cancer. 2021 Jan;1875(1):188489. (PMID: 33278512)
      Benef Microbes. 2020 Sep 1;11(5):411-455. (PMID: 32865024)
      EMBO Rep. 2006 Jul;7(7):688-93. (PMID: 16819463)
      Microbiol Spectr. 2023 Jan 31;:e0281922. (PMID: 36719190)
      Front Immunol. 2019 Mar 11;10:277. (PMID: 30915065)
      BMC Microbiol. 2021 Aug 28;21(1):238. (PMID: 34454437)
      Front Microbiol. 2018 Jun 13;9:1274. (PMID: 29951050)
      J Pediatr. 2015 Sep;167(3):527-32.e1-3. (PMID: 25982142)
      Immunol Rev. 2017 Sep;279(1):90-105. (PMID: 28856737)
      Proc Nutr Soc. 2021 Feb;80(1):37-49. (PMID: 32238208)
      Int J Obes (Lond). 2020 May;44(5):1075-1086. (PMID: 31911660)
      Immunology. 2013 Jan;138(1):1-11. (PMID: 23240815)
      Nat Commun. 2021 Nov 19;12(1):6757. (PMID: 34799562)
      Clin Microbiol Rev. 2007 Oct;20(4):593-621. (PMID: 17934076)
      Bioinformatics. 2011 Aug 15;27(16):2194-200. (PMID: 21700674)
    • Grant Information:
      82030020 Key Project of the National Natural Science Foundation of China
    • Contributed Indexing:
      Keywords: Benign polyps; Gut microbiota; Peutz–Jeghers syndrome; Serine/threonine kinase 11; Short chain fatty acids
    • Accession Number:
      0 (Fatty Acids, Volatile)
      0 (Butyrates)
    • Publication Date:
      Date Created: 20231130 Date Completed: 20231204 Latest Revision: 20240917
    • Publication Date:
      20240917
    • Accession Number:
      PMC10688050
    • Accession Number:
      10.1186/s12866-023-03132-0
    • Accession Number:
      38036954