Inhibitory effects of Curcumae Radix carbonisata -based carbon dots against liver fibrosis induced by carbon tetrachloride in mice.

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  • Additional Information
    • Source:
      Publisher: Taylor & Francis Country of Publication: England NLM ID: 101594777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2169-141X (Electronic) Linking ISSN: 21691401 NLM ISO Abbreviation: Artif Cells Nanomed Biotechnol Subsets: MEDLINE
    • Publication Information:
      Publication: 2015- : Abingdon, Oxford : Taylor & Francis
      Original Publication: London : Informa Healthcare, [2013]-
    • Subject Terms:
      Liver*/metabolism ; Carbon Tetrachloride*/metabolism ; Carbon Tetrachloride*/pharmacology; Mice ; Animals ; Carbon/pharmacology ; Liver Cirrhosis/chemically induced ; Liver Cirrhosis/drug therapy ; Bilirubin/metabolism ; Bilirubin/pharmacology ; Oxidative Stress
    • Abstract:
      As a processed product of traditional Chinese medicine Curcumae Radix , Curcumae Radix Carbonisata (CRC) has been widely used in the treatment of liver diseases in ancient medical books. In this study, novel carbon dots (CDs) extending from 1.0 to 4.5 nm were separated from fluid extricates of CRC. Meanwhile, a liver fibrosis model induced by carbon tetrachloride (CCl 4 ) was utilized to determine the inhibitory effects of CRC-CDs against liver fibrosis. The results exhibited the CRC-CDs with a quantum yield of 1.34% have a significant inhibitory effect on CCl 4 -induced liver fibrosis, as demonstrated by improving hepatocyte degeneration and necrosis, inflammatory cell infiltration and fibrotic tissue hyperplasia, downregulating the levels of alanine transaminase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), direct bilirubin (DBIL), total bile acid (TBA), triglyceride (TG), tumour necrosis factor-α (TNF-α), interleukin (IL)-6 and IL-1β in the serum, upregulating the contents of superoxide dismutase (SOD), reduced glutathione (GSH), and downregulating the concentration of malondialdehyde (MDA), which lays an important foundation for the development of CRC-CDs as a novel drug for the treatment of liver fibrosis, and provide a certain experimental basis for the clinical application of CRC-CDs in the future.
    • Contributed Indexing:
      Keywords: Curcumae radix carbonisata; carbon dots; carbon tetrachloride; inhibitory effect; liver fibrosis
    • Accession Number:
      CL2T97X0V0 (Carbon Tetrachloride)
      7440-44-0 (Carbon)
      RFM9X3LJ49 (Bilirubin)
    • Publication Date:
      Date Created: 20231130 Date Completed: 20231204 Latest Revision: 20231204
    • Publication Date:
      20231204
    • Accession Number:
      10.1080/21691401.2023.2239522
    • Accession Number:
      38035609