Diet and Chronic Disease Research in the Women's Health Initiative.

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  • Author(s): Prentice RL;Prentice RL;Prentice RL
  • Source:
    Journal of the Academy of Nutrition and Dietetics [J Acad Nutr Diet] 2024 Nov; Vol. 124 (11), pp. 1402-1408. Date of Electronic Publication: 2023 Nov 22.
  • Publication Type:
    Journal Article; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: United States NLM ID: 101573920 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2212-2672 (Print) Linking ISSN: 22122672 NLM ISO Abbreviation: J Acad Nutr Diet Subsets: MEDLINE
    • Publication Information:
      Original Publication: New York : Elsevier
    • Subject Terms:
      Biomarkers*/blood ; Biomarkers*/urine ; Chronic Disease*/prevention & control ; Diet, Fat-Restricted* ; Women's Health*; Female ; Humans ; Middle Aged ; Breast Neoplasms/prevention & control ; Dietary Supplements ; Fruit ; Postmenopause ; Randomized Controlled Trials as Topic ; United States ; Vegetables ; Vitamin D/administration & dosage ; Vitamin D/blood
    • Abstract:
      The Women's Health Initiative (WHI) has been a major contributor to diet and chronic disease research among postmenopausal US women over its 30+ year history (1993 to present). The WHI program included full-scale randomized trials of a low-fat dietary pattern high in fruits, vegetables, and grains, and of calcium and vitamin D supplementation, each with designated primary and secondary chronic disease outcomes. The history of these trials will be briefly reviewed here, along with principal findings that included evidence for breast cancer-related benefits for each of the 2 interventions. In recent years, WHI investigators have developed an active research program in nutritional biomarker development and in the application of these biomarkers in WHI cohorts, among various other nutritional epidemiology uses of WHI observational study resources. The intake biomarker work, which primarily relies on blood and urine metabolomics profiles, lends support to the low-fat dietary pattern trial results, and supports chronic disease benefits of higher carbohydrate diets more generally, especially through the fiber component of carbohydrate.
      (Copyright © 2024 Academy of Nutrition and Dietetics. Published by Elsevier Inc. All rights reserved.)
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    • Grant Information:
      HHSN268201600002C United States HL NHLBI NIH HHS; P30 CA015704 United States CA NCI NIH HHS; HHSN271201600004I United States DA NIDA NIH HHS; HHSN268201600004C United States HL NHLBI NIH HHS; HHSN268201600001C United States HL NHLBI NIH HHS; HHSN268201600003C United States HL NHLBI NIH HHS; HHSN271201600004C United States DA NIDA NIH HHS; R01 CA119171 United States CA NCI NIH HHS
    • Accession Number:
      0 (Biomarkers)
      1406-16-2 (Vitamin D)
    • Publication Date:
      Date Created: 20231124 Date Completed: 20241019 Latest Revision: 20241105
    • Publication Date:
      20241106
    • Accession Number:
      PMC11109020
    • Accession Number:
      10.1016/j.jand.2023.11.012
    • Accession Number:
      38000690