Validation of symptom measures in patients under investigation for postural orthostatic tachycardia syndrome (POTS): The Orthostatic Grading Scale (OGS) and the Symptom Screen for Small-fiber Polyneuropathy (SSS).

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  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: Netherlands NLM ID: 100909359 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7484 (Electronic) Linking ISSN: 15660702 NLM ISO Abbreviation: Auton Neurosci Subsets: MEDLINE
    • Publication Information:
      Original Publication: [Amsterdam ; New York] : Elsevier, c2000-
    • Subject Terms:
      Postural Orthostatic Tachycardia Syndrome*/diagnosis; Humans ; Reproducibility of Results
    • Abstract:
      Objectives: Postural Orthostatic Tachycardia Syndrome (POTS) presents with a range of poorly delineated symptoms across several domains. There is an urgent need for standardized symptom reporting in POTS, but a lack of validated symptom burden instruments. Our aim was to evaluate the psychometric properties of two symptom burden measures: the Orthostatic Grading Scale (OGS) and the Symptom Screen for Small-Fiber Polyneuropathy (SSS), in patients under investigation for suspected POTS.
      Design: Psychometric validation study.
      Methods: Confirmatory factor analysis (CFA) tested the factor structure of the SSS and OGS completed by 149 patients under investigation for POTS. Scale reliability and validity were assessed. The uni-dimensionality of the SSS was assessed through principal component analysis (PCA).
      Results: CFA of the OGS revealed that a 1-factor structure had adequate fit. CFA of the SSS revealed that a 5-factor structure had generally appropriate fit supporting the originally proposed 5 factors (1: Gastrointestinal, 2: Somatosensory, 3: Miscellaneous, 4: Microvascular, and 5: Urological). In addition, the SSS demonstrated sufficient uni-dimensionality in the PCA, warranting use of a single total score. Omega coefficients of both measures indicated satisfactory internal reliability (0.668-0.931). Correlations with related constructs (distress (K10 score), r = 0.317-0.404, p < 0.001) and heart rate indices (with the OGS, r = 0.211-0.294, p < 0.05) suggested sound convergent and divergent validity.
      Conclusions: Initial evidence suggests that the OGS and SSS have good psychometric properties for use in populations with suspected and confirmed POTS.
      (Copyright © 2023 Elsevier B.V. All rights reserved.)
    • Contributed Indexing:
      Keywords: Orthostatic symptoms; Postural Orthostatic Tachycardia Syndrome (POTS); Psychometric validation; Small-fiber neuropathy; Symptom burden; Symptom questionnaires
    • Publication Date:
      Date Created: 20231117 Date Completed: 20231216 Latest Revision: 20231227
    • Publication Date:
      20231228
    • Accession Number:
      10.1016/j.autneu.2023.103130
    • Accession Number:
      37976608