Multidrug-resistant Corynebacterium diphtheriae in people with travel history from West Africa to France, March to September 2023.

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  • Additional Information
    • Source:
      Publisher: European Centre for Disease Prevention and Control (ECDC) Country of Publication: Sweden NLM ID: 100887452 Publication Model: Print Cited Medium: Internet ISSN: 1560-7917 (Electronic) Linking ISSN: 1025496X NLM ISO Abbreviation: Euro Surveill Subsets: MEDLINE
    • Publication Information:
      Publication: Stockholm, Sweden : European Centre for Disease Prevention and Control (ECDC)
      Original Publication: Saint-Maurice : Hôpital national de Saint-Maurice
    • Subject Terms:
      Corynebacterium diphtheriae*/genetics ; Diphtheria*/diagnosis ; Diphtheria*/drug therapy ; Diphtheria*/epidemiology; Humans ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; France/epidemiology ; Mali
    • Abstract:
      We describe 10 unlinked cases of Corynebacterium diphtheriae infection (nine cutaneous, one respiratory) in France in 2023 in persons travelling from Guinea, Mali, Senegal, Niger or Nigeria and Central African Republic. Four isolates were toxigenic. Seven genomically unrelated isolates were multidrug-resistant, including a toxigenic respiratory isolate with high-level resistance to macrolides and beta-lactams. The high rates of resistance, including against first-line agents, call for further microbiological investigations to guide clinical management and public health response in ongoing West African outbreaks.
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    • Contributed Indexing:
      Keywords: Africa; Diphtheria; antimicrobial resistance; genomic epidemiology; outbreaks
    • Accession Number:
      0 (Anti-Bacterial Agents)
    • Publication Date:
      Date Created: 20231116 Date Completed: 20231127 Latest Revision: 20240112
    • Publication Date:
      20240112
    • Accession Number:
      PMC10655204
    • Accession Number:
      10.2807/1560-7917.ES.2023.28.46.2300615
    • Accession Number:
      37971662