Bilateral angle closure glaucoma with retinitis pigmentosa in young patients: case series.

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  • Additional Information
    • Source:
      Publisher: BioMed Central Country of Publication: England NLM ID: 100967802 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2415 (Electronic) Linking ISSN: 14712415 NLM ISO Abbreviation: BMC Ophthalmol Subsets: MEDLINE
    • Publication Information:
      Original Publication: London : BioMed Central, [2001-
    • Subject Terms:
      Glaucoma, Angle-Closure*/complications ; Glaucoma, Angle-Closure*/diagnosis ; Glaucoma, Angle-Closure*/surgery ; Laser Therapy* ; Retinitis Pigmentosa*/complications ; Retinitis Pigmentosa*/diagnosis; Middle Aged ; Humans ; Iridectomy ; Iris/surgery ; Treatment Outcome ; Intraocular Pressure ; DNA-Binding Proteins ; Transcription Factors
    • Abstract:
      Background: To report the ocular characteristics and management of three cases of retinitis pigmentosa (RP) concurrent primary angle closure glaucoma (PACG).
      Case Presentation: Three middle-aged patients presenting with diminished vision, high intraocular pressure (IOP), and typical fundus manifestations of RP were clinically evaluated. The individualized treatment was based on the ocular conditions of each case. A novel genetic alteration in ZNF408 was identified in one patient. Two patients with short-axial eyes received unilateral combined trabeculectomy, cataract surgery, and Irido-zonulo-hyaloid-vitrectomy. One of them had a subluxated lens, managed with a capsular tension ring implantation. Their contralateral eyes, respectively, underwent laser peripheral iridotomy (LPI) and transscleral cyclophotocoagulation. The third patient underwent bilaterally combined laser peripheral iridoplasty, LPI, and medication. Ultimately, all patients achieved the target IOP during a two-year follow-up.
      Conclusion: Young patients with RP may have a risk of developing angle closure glaucoma, and conversely, patients with angle closure glaucoma at younger age should be aware of the presence of RP. Therefore, routine gonioscopy and IOP monitoring are required for RP patients, and detailed fundus examinations are warranted for young PACG patients.
      (© 2023. The Author(s).)
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    • Grant Information:
      cstc2020jcyj-msxmX1097 Chongqing Science and Technology Commission of China
    • Contributed Indexing:
      Keywords: Primary angle closure glaucoma; Retinitis pigmentosa; ZNF408
    • Accession Number:
      0 (ZNF408 protein, human)
      0 (DNA-Binding Proteins)
      0 (Transcription Factors)
    • Publication Date:
      Date Created: 20231116 Date Completed: 20231117 Latest Revision: 20231119
    • Publication Date:
      20231119
    • Accession Number:
      PMC10648655
    • Accession Number:
      10.1186/s12886-023-03190-y
    • Accession Number:
      37968604