Whole blood viscosity is associated with reduced myocardial mechano-energetic efficiency in nondiabetic individuals.

Publisher: Wiley Country of Publication: England NLM ID: 0245331 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2362 (Electronic) Linking ISSN: 00142972 NLM ISO Abbreviation: Eur J Clin Invest Subsets: MEDLINE

Publication: Oxford : Wiley
Original Publication: Berlin, New York, Springer-Verlag, on behalf of the European Society for Clinical Investigation.

Insulin Resistance*; Adult ; Male ; Female ; Humans ; Middle Aged ; Cross-Sectional Studies ; Blood Viscosity ; Glucose ; Blood Proteins ; Blood Glucose/metabolism ; Body Mass Index

Introduction: This cross-sectional study aimed to investigate the association between myocardial mechano-energetic efficiency (MEE) and whole blood viscosity (WBV) in nondiabetic adults participating in the CATAnzaro MEtabolic RIsk factors (CATAMERI) study.
Methods: 1143 participants underwent an oral glucose tolerance test and an echocardiogram for myocardial MEE per gram of left ventricular mass (MEEi) measurement. WBV was measured as: [0.12 × h] + [0.17 × (p-2.07)], where h is haematocrit and p is plasma protein levels.
Results: Study population includes 595 males and 548 females with a mean age of 46 ± 12 years and a mean BMI of 30.0 ± 6.2 kg/m ² . Individuals with normal glucose tolerance were 63%, while those with impaired fasting glucose, impaired glucose tolerance and or the combination of both were 14.3%, 13% and 9.7%, respectively. A univariate analysis showed that MEEi was significantly associated with sex, age, smoking, BMI, waist circumference, total cholesterol, HDL, triglycerides, fasting glucose, fasting insulin, HOMA-IR index, glucose tolerance, C-reactive protein, haematocrit, haemoglobin, plasma protein and WBV. In a multivariable regression model including variables that were significantly associated with MEEi in univariate analysis, MEEi was associated with HOMA-IR (β = -0.144, p < .001), age (β = -0.140, p < .001), WBV (β = -0.129, p < .001) and glucose tolerance (β = -0.064, p = .04). The independent association between WBV and MEEi remained statistically significant (β = -0.122, p < .001) when antihypertensive therapy and lipid-lowering therapy were included in the model.
Conclusion: WBV is associated with decreased myocardial MEE independently of other cardiovascular risk factors.
(© 2023 The Authors. European Journal of Clinical Investigation published by John Wiley & Sons Ltd on behalf of Stichting European Society for Clinical Investigation Journal Foundation.)

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EFSD/Lilly Young Investigator Research Award European Association for the Study of Diabetes; 2020N5WK98_005 Ministero dell'Università e della Ricerca; Mario Condorelli Award Società Italiana di Medicina Interna; RM1201728887461F University of Rome La Sapienza

Keywords: CATAMERI; cardiac energetics; cardiovascular disease; haematocrit; left ventricular function

IY9XDZ35W2 (Glucose)
0 (Blood Proteins)
0 (Blood Glucose)

Date Created: 20231111 Date Completed: 20240214 Latest Revision: 20240214

20240214

10.1111/eci.14127

37950492