The dual-action mechanism of Arabidopsis cryptochromes.

Publisher: Wiley-Blackwell Pub Country of Publication: China (Republic : 1949- ) NLM ID: 101250502 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-7909 (Electronic) Linking ISSN: 16729072 NLM ISO Abbreviation: J Integr Plant Biol Subsets: MEDLINE

Publication: [China] : Wiley-Blackwell Pub
Original Publication: [Carlton South, Victoria] : Blackwell Pub., 2005-

Cryptochromes*/metabolism ; Cryptochromes*/chemistry ; Cryptochromes*/genetics ; Arabidopsis*/metabolism ; Arabidopsis*/genetics ; Arabidopsis Proteins*/metabolism ; Arabidopsis Proteins*/genetics ; Arabidopsis Proteins*/chemistry; Light ; Gene Expression Regulation, Plant

Photoreceptor cryptochromes (CRYs) mediate blue-light regulation of plant growth and development. It has been reported that Arabidopsis CRY1and CRY2 function by physically interacting with at least 84 proteins, including transcription factors or co-factors, chromatin regulators, splicing factors, messenger RNA methyltransferases, DNA repair proteins, E3 ubiquitin ligases, protein kinases and so on. Of these 84 proteins, 47 have been reported to exhibit altered binding affinity to CRYs in response to blue light, and 41 have been shown to exhibit condensation to CRY photobodies. The blue light-regulated composition or condensation of CRY complexes results in changes of gene expression and developmental programs. In this mini-review, we analyzed recent studies of the photoregulatory mechanisms of Arabidopsis CRY complexes and proposed the dual mechanisms of action, including the "Lock-and-Key" and the "Liquid-Liquid Phase Separation (LLPS)" mechanisms. The dual CRY action mechanisms explain, at least partially, the structural diversity of CRY-interacting proteins and the functional diversity of the CRY photoreceptors.
(© 2023 The Authors. Journal of Integrative Plant Biology published by John Wiley & Sons Australia, Ltd on behalf of Institute of Botany, Chinese Academy of Sciences.)

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32000155 National Natural Science Foundation of China; 32330009 National Natural Science Foundation of China

Keywords: Arabidopsis; CRY1; CRY2; blue light; cryptochrome; phase separation

0 (Cryptochromes)
0 (Arabidopsis Proteins)

Date Created: 20231030 Date Completed: 20240527 Latest Revision: 20240531

20240531

10.1111/jipb.13578

37902426