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Risk factors for fibrosis progression in non-alcoholic steatohepatitis: Analysis of the European cohort in the real-world GAIN study.
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- Author(s): Shaikh A;Shaikh A; Pedra G; Pedra G; Ruiz-Casas L; Ruiz-Casas L; Franks B; Franks B; Dhillon H; Dhillon H; Fernandes JDDR; Fernandes JDDR; Mangla KK; Mangla KK; Augusto M; Augusto M; Romero-Gómez M; Romero-Gómez M; Romero-Gómez M; Schattenberg JM; Schattenberg JM
- Source:
Gastroenterologia y hepatologia [Gastroenterol Hepatol] 2024 May; Vol. 47 (5), pp. 463-472. Date of Electronic Publication: 2023 Oct 27.- Publication Type:
Journal Article; Multicenter Study- Language:
English; Spanish; Castilian - Source:
- Additional Information
- Source: Publisher: Elsevier España Country of Publication: Spain NLM ID: 8406671 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 0210-5705 (Print) Linking ISSN: 02105705 NLM ISO Abbreviation: Gastroenterol Hepatol Subsets: MEDLINE
- Publication Information: Publication: Madrid : Elsevier España
Original Publication: Barcelona : Ediciones Doyma, SL - Subject Terms: Non-alcoholic Fatty Liver Disease*/epidemiology ; Non-alcoholic Fatty Liver Disease*/pathology ; Disease Progression* ; Liver Cirrhosis*/etiology ; Liver Cirrhosis*/pathology ; Liver Cirrhosis*/epidemiology; Humans ; Female ; Male ; Middle Aged ; Risk Factors ; Europe/epidemiology ; Adult ; Liver Transplantation ; Aged ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/epidemiology ; Cohort Studies ; Biopsy
- Abstract: Objective: To better understand drivers of disease progression in non-alcoholic steatohepatitis (NASH), we assessed clinical and sociodemographic markers of fibrosis progression in adults with NASH.
Patients and Methods: Physician-reported patient demographics and clinical characteristics were utilised from the real-world Global Assessment of the Impact of NASH (GAIN) study. Factors associated with likelihood of fibrosis progression since NASH diagnosis were identified using a logistic regression model.
Results: Overall, 2349 patients in Europe from the GAIN study were included; mean age was 54.6 years and 41% were women. Significant covariates included age, years since diagnosis, employment status, fibrosis stage at diagnosis, type 2 diabetes mellitus, hypertension, liver transplant and liver biopsy at diagnosis. Risk of progression was 1.16 (95% confidence interval 1.12-1.20; p<0.001) times higher for each additional year since NASH diagnosis and 5.43 (2.68-11.37; p<0.001) times higher when physicians proposed a liver transplant at diagnosis. Compared with full-time employed patients, risk of progression was 1.77 (1.19-2.60; p=0.004) times higher for unemployed patients and 3.16 (1.30-7.63; p=0.010) times higher for those unable to work due to NASH.
Conclusions: Disease duration, NASH severity and presence of other metabolic comorbidities could help to assess risk of progression in patients with NASH.
(Copyright © 2023 The Author(s). Publicado por Elsevier España, S.L.U. All rights reserved.) - Contributed Indexing: Keywords: Advanced fibrosis; Biopsia hepática; Enfermedad del hígado graso sin alcohol; Esteatohepatitis no alcohólica; Factor de riesgo; Fibrosis avanzada; Liver biopsy; Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Risk factor
- Publication Date: Date Created: 20231027 Date Completed: 20240430 Latest Revision: 20240516
- Publication Date: 20240516
- Accession Number: 10.1016/j.gastrohep.2023.10.005
- Accession Number: 37890583
- Source:
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