Menu
×
West Ashley Library
9 a.m. - 7 p.m.
Phone: (843) 766-6635
Folly Beach Library
9 a.m. - 5:30 p.m.
Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
Wando Mount Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. - 6 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. - 8 p.m.
Phone: (843) 889-3300
Otranto Road Library
9 a.m. - 8 p.m.
Phone: (843) 572-4094
Mt. Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 849-6161
McClellanville Library
9 a.m. - 6 p.m.
Phone: (843) 887-3699
Keith Summey North Charleston Library
9 a.m. - 8 p.m.
Phone: (843) 744-2489
John's Island Library
9 a.m. - 8 p.m.
Phone: (843) 559-1945
Hurd/St. Andrews Library
9 a.m. - 8 p.m.
Phone: (843) 766-2546
Miss Jane's Building (Edisto Library Temporary Location)
9 a.m. - 4 p.m.
Phone: (843) 869-2355
Dorchester Road Library
9 a.m. - 8 p.m.
Phone: (843) 552-6466
John L. Dart Library
9 a.m. - 7 p.m.
Phone: (843) 722-7550
Baxter-Patrick James Island
9 a.m. - 8 p.m.
Phone: (843) 795-6679
Main Library
9 a.m. - 8 p.m.
Phone: (843) 805-6930
Bees Ferry West Ashley Library
9 a.m. - 8 p.m.
Phone: (843) 805-6892
Mobile Library
9 a.m. - 5 p.m.
Phone: (843) 805-6909
Today's Hours
West Ashley Library
9 a.m. - 7 p.m.
Phone: (843) 766-6635
Folly Beach Library
9 a.m. - 5:30 p.m.
Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
Wando Mount Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. - 6 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. - 8 p.m.
Phone: (843) 889-3300
Otranto Road Library
9 a.m. - 8 p.m.
Phone: (843) 572-4094
Mt. Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 849-6161
McClellanville Library
9 a.m. - 6 p.m.
Phone: (843) 887-3699
Keith Summey North Charleston Library
9 a.m. - 8 p.m.
Phone: (843) 744-2489
John's Island Library
9 a.m. - 8 p.m.
Phone: (843) 559-1945
Hurd/St. Andrews Library
9 a.m. - 8 p.m.
Phone: (843) 766-2546
Miss Jane's Building (Edisto Library Temporary Location)
9 a.m. - 4 p.m.
Phone: (843) 869-2355
Dorchester Road Library
9 a.m. - 8 p.m.
Phone: (843) 552-6466
John L. Dart Library
9 a.m. - 7 p.m.
Phone: (843) 722-7550
Baxter-Patrick James Island
9 a.m. - 8 p.m.
Phone: (843) 795-6679
Main Library
9 a.m. - 8 p.m.
Phone: (843) 805-6930
Bees Ferry West Ashley Library
9 a.m. - 8 p.m.
Phone: (843) 805-6892
Mobile Library
9 a.m. - 5 p.m.
Phone: (843) 805-6909
Patron Login
menu
Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
[Androgen deprivation therapy and cardiovascular morbidity in prostate cancer: a narrative review].
Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
- Author(s): Klemm J;Klemm J;Klemm J; von Deimling M; von Deimling M; von Deimling M; Fisch M; Fisch M; Kramer G; Kramer G; Tilki D; Tilki D; Tilki D; Tilki D; Steuber T; Steuber T; von Amsberg G; von Amsberg G; von Amsberg G; Hengstenberg C; Hengstenberg C; Shariat SF; Shariat SF; Shariat SF; Shariat SF; Shariat SF; Shariat SF; Shariat SF
- Source:
Urologie (Heidelberg, Germany) [Urologie] 2024 Mar; Vol. 63 (3), pp. 262-268. Date of Electronic Publication: 2023 Oct 24.- Publication Type:
English Abstract; Journal Article; Review- Language:
German - Source:
- Additional Information
- Transliterated Title: Androgendeprivationstherapie und kardiovaskuläre Morbidität beim Prostatakarzinom: ein narratives Review.
- Source: Publisher: Springer Medizin Country of Publication: Germany NLM ID: 9918384886606676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2731-7072 (Electronic) Linking ISSN: 27317064 NLM ISO Abbreviation: Urologie Subsets: MEDLINE
- Publication Information: Original Publication: [Heidelberg, Germany] : Springer Medizin, [2022]-
- Subject Terms:
- Abstract: Prostate cancer is the most common malignancy in men, mostly affecting older men who harbor an increased prevalence of cardiovascular disease and metabolic syndrome. Androgen deprivation therapy (ADT), the standard therapy for various stages of prostate cancer, further increases the risk for cardiovascular disease and for metabolic syndrome. Therefore, screening for cardiovascular risk factors should be performed prior to the initiation of ADT, and, if necessary, cardiological evaluation and interdisciplinary management should be provided during and after completion of ADT. Moreover, the use of a gonadotropin-releasing hormone (GnRH) antagonist may help reduce cardiovascular risk in patients with cardiovascular disease.
(© 2023. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.) - References: Sung H, Ferlay J, Siegel RL et al (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71:209–249. (PMID: 10.3322/caac.2166033538338)
Siegel RL, Miller KD, Fuchs HE et al (2022) Cancer statistics, 2022. CA Cancer J Clin 72:7–33. (PMID: 3502020410.3322/caac.21708)
Studer UE, Whelan P, Albrecht W et al (2006) Immediate or deferred androgen deprivation for patients with prostate cancer not suitable for local treatment with curative intent: European Organisation for Research and Treatment of Cancer (EORTC) Trial 30891. J Clin Oncol 24:1868–1876. (PMID: 1662226110.1200/JCO.2005.04.7423)
Elmehrath AO, Afifi AM, Al-Husseini MJ et al (2021) Causes of death among patients with metastatic prostate cancer in the US from 2000 to 2016. Jama Netw Open 4:e2119568. (PMID: 34351403834346710.1001/jamanetworkopen.2021.19568)
Kokorovic A, So AI, Serag H et al (2022) UPDATE—Canadian urological association guideline on androgen deprivation therapy: adverse events and management strategies summary of changes. Can Urol Assoc J 16:243–244. (PMID: 35905484934315910.5489/cuaj.8007)
Cornford P, Van Den Bergh RCN, Briers E et al (2021) EAU-EANM-ESTRO-ESUR-SIOG guidelines on prostate cancer. Part II-2020 update: treatment of relapsing and metastatic prostate cancer. Eur Urol 79:263–282. (PMID: 3303920610.1016/j.eururo.2020.09.046)
Oefelein MG, Feng A, Scolieri MJ et al (2000) Reassessment of the definition of castrate levels of testosterone: implications for clinical decision making. Urology 56:1021–1024. (PMID: 1111375110.1016/S0090-4295(00)00793-7)
Seidenfeld J, Samson DJ, Hasselblad V et al (2000) Single-therapy androgen suppression in men with advanced prostate cancer: a systematic review and meta-analysis. Ann Intern Med 132:566–577. (PMID: 1074459410.7326/0003-4819-132-7-200004040-00009)
Mottet N, Van Den Bergh RCN, Briers E et al (2021) EAU-EANM-ESTRO-ESUR-SIOG guidelines on prostate cancer-2020 update. Part 1: screening, diagnosis, and local treatment with curative intent. Eur Urol 79:243–262. (PMID: 3317272410.1016/j.eururo.2020.09.042)
Riaz IB, Naqvi Sa A, He H et al (2023) First-line systemic treatment options for metastatic castration-sensitive prostate cancer: a living systematic review and network meta-analysis, JAMA Oncol. Aufl.
Saigal CS, Gore JL, Krupski TL et al (2007) Androgen deprivation therapy increases cardiovascular morbidity in men with prostate cancer. Cancer 110:1493–1500. (PMID: 1765781510.1002/cncr.22933)
Liang Z, Zhu J, Chen L et al (2020) Is androgen deprivation therapy for prostate cancer associated with cardiovascular disease? A meta-analysis and systematic review. Andrology 8:559–574. (PMID: 3174359410.1111/andr.12731)
Khoshkar Y, Vigneswaran HT, Eloranta S et al (2022) Cardiovascular, bone, and metabolic health in men with castrate-resistant prostate cancer treated with androgen deprivation: a matched cohort study. Acta Oncol 61:1377–1385. (PMID: 3644863010.1080/0284186X.2022.2141077)
Kulkarni AA, Rubin N, Tholkes A et al (2021) Risk for stroke and myocardial infarction with abiraterone versus enzalutamide in metastatic prostate cancer patients. Esmo Open 6:100261. (PMID: 34509804843777710.1016/j.esmoop.2021.100261)
Iacovelli R, Ciccarese C, Bria E et al (2018) The cardiovascular toxicity of Abiraterone and Enzalutamide in prostate cancer. Clin Genitourin Cancer 16:e645–e653. (PMID: 2933904410.1016/j.clgc.2017.12.007)
Armstrong AJ, Lin P, Tombal B et al (2020) Five-year survival prediction and safety outcomes with Enzalutamide in men with chemotherapy-naïve metastatic castration-resistant prostate cancer from the PREVAIL trial. Eur Urol 78:347–357. (PMID: 3252769210.1016/j.eururo.2020.04.061)
O’farrell S, Garmo H, Holmberg L et al (2015) Risk and timing of cardiovascular disease after androgen-deprivation therapy in men with prostate cancer. J Clin Oncol 33:1243–1251. (PMID: 2573216710.1200/JCO.2014.59.1792)
Anonymous (2020) Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the global burden of disease study 2019. Lancet 396:1204–1222. (PMID: 10.1016/S0140-6736(20)30925-9)
Albertsen PC, Klotz L, Tombal B et al (2014) Cardiovascular morbidity associated with gonadotropin releasing hormone agonists and an antagonist. Eur Urol 65:565–573. (PMID: 2421009010.1016/j.eururo.2013.10.032)
Cirne F, Aghel N, Petropoulos JA et al (2022) The cardiovascular effects of gonadotropin-releasing hormone antagonists in men with prostate cancer. Eur Heart J Cardiovasc Pharmacother 8:253–262. (PMID: 3347040310.1093/ehjcvp/pvab005)
Abufaraj M, Iwata T, Kimura S et al (2021) Differential impact of gonadotropin-releasing hormone antagonist versus agonist on clinical safety and oncologic outcomes on patients with metastatic prostate cancer: a meta-analysis of randomized controlled trials. Eur Urol 79:44–53. (PMID: 3260585910.1016/j.eururo.2020.06.002)
Von Amsberg G, Thiele H, Merseburger A (2021) Cardiovascular side effects in patients undergoing androgen deprivation therapy: superiority of gonadotropin-releasing hormone antagonists? An update. Urol Ausg A 60:1450–1457.
Merseburger AS, Sedding D, Hüter K (2016) Cardiovascular risk patients under androgen deprivation therapy: lower risk with GnRH antagonists compared to LHRH agonists? Urol Ausg A 55:218–225. (PMID: 10.1007/s00120-015-0013-1)
Margel D, Peer A, Ber Y et al (2019) Cardiovascular morbidity in a randomized trial comparing GnRH agonist and GnRH antagonist among patients with advanced prostate cancer and preexisting cardiovascular disease. J Urol 202:1199–1208. (PMID: 3118873410.1097/JU.0000000000000384)
Shore ND, Saad F, Cookson MS et al (2020) Oral Relugolix for androgen-deprivation therapy in advanced prostate cancer. N Engl J Med 382:2187–2196. (PMID: 3246918310.1056/NEJMoa2004325)
Hopmans SN, Duivenvoorden WCM, Werstuck GH et al (2014) GnRH antagonist associates with less adiposity and reduced characteristics of metabolic syndrome and atherosclerosis compared with orchiectomy and GnRH agonist in a preclinical mouse model1Contributed equally and share first authorship. Urol Oncol Seminars Orig Investig 32:1126–1134.
Lopes RD, Higano CS, Slovin SF et al (2021) Cardiovascular safety of Degarelix versus Leuprolide in patients with prostate cancer: the primary results of the PRONOUNCE randomized trial. Circulation 144:1295–1307. (PMID: 34459214900431910.1161/CIRCULATIONAHA.121.056810)
Ng CF, Teoh JYC, Chiu PKF (2022) Letter by Ng et al regarding article, “cardiovascular safety of Degarelix versus Leuprolide in patients with prostate cancer: the primary results of the PRONOUNCE randomized trial”. Circulation 145:e773–e774. (PMID: 3531238310.1161/CIRCULATIONAHA.121.057407)
Wallach JD, Deng Y, Mccoy RG et al (2021) Real-world cardiovascular outcomes associated with Degarelix vs Leuprolide for prostate cancer treatment. Jama Netw Open 4:e2130587. (PMID: 34677594853695510.1001/jamanetworkopen.2021.30587)
George G, Garmo H, Scailteux LM et al (2021) Risk of cardiovascular disease following gonadotropin-releasing hormone agonists vs antagonists in prostate cancer: Real-world evidence from five databases. Int J Cancer 148:2203–2211. (PMID: 3318648110.1002/ijc.33397)
Zengerling F, Jakob JJ, Schmidt S et al (2021) Degarelix for treating advanced hormone-sensitive prostate cancer. Cochrane Database Syst Rev 8:Cd12548. (PMID: 34350976)
Lyon AR, López-Fernández T, Couch LS et al (2022) 2022 ESC guidelines on cardio-oncology developed in collaboration with the European hematology association (EHA), the European society for therapeutic radiology and oncology (ESTRO) and the international Cardio-oncology society (IC-OS): developed by the task force on cardio-oncology of the European society of cardiology (ESC). Eur Heart J 43:4229–4361. (PMID: 3601756810.1093/eurheartj/ehac244)
Timmis A, Vardas P, Townsend N et al (2022) European society of cardiology: cardiovascular disease statistics 2021. Eur Heart J 43:716–799. (PMID: 3501620810.1093/eurheartj/ehab892)
Kassi E, Pervanidou P, Kaltsas G et al (2011) Metabolic syndrome: definitions and controversies. BMC Med 9:48. (PMID: 21542944311589610.1186/1741-7015-9-48)
Belladelli F, Montorsi F, Martini A (2022) Metabolic syndrome, obesity and cancer risk. Curr Opin Urol 32:594–597. (PMID: 3608139610.1097/MOU.0000000000001041)
Bosco C, Crawley D, Adolfsson J et al (2015) Quantifying the evidence for the risk of metabolic syndrome and its components following androgen deprivation therapy for prostate cancer: a meta-analysis. PLoS ONE 10:e117344. (PMID: 25794005436863010.1371/journal.pone.0117344)
Morote J, Gómez-Caamaño A, Alvarez-Ossorio JL et al (2015) The metabolic syndrome and its components in patients with prostate cancer on androgen deprivation therapy. J Urol 193:1963–1969. (PMID: 2554134010.1016/j.juro.2014.12.086)
Gacci M, Russo GI, De Nunzio C et al (2017) Meta-analysis of metabolic syndrome and prostate cancer. Prostate Cancer Prostatic Dis 20:146–155. (PMID: 2822080510.1038/pcan.2017.1)
Levine GN, D’amico AV, Berger P et al (2010) Androgen-deprivation therapy in prostate cancer and cardiovascular risk: a science advisory from the American heart association, American cancer society, and American urological association: endorsed by the American society for radiation oncology. CA Cancer J Clin 60:194–201. (PMID: 20124400304994310.3322/caac.20061)
Kenk M, Grégoire JC, Coté MA et al (2020) Optimizing screening and management of cardiovascular health in prostate cancer: A review. Can Urol Assoc J 14:E458–e464. (PMID: 32569573749203110.5489/cuaj.6685)
Roth GA, Mensah GA, Johnson CO et al (2020) Global burden of cardiovascular diseases and risk factors, 1990–2019: update from the GBD 2019 study. J Am Coll Cardiol 76:2982–3021. (PMID: 33309175775503810.1016/j.jacc.2020.11.010)
Tombal B (2009) A holistic approach to androgen deprivation therapy: treating the cancer without hurting the patient. Urol Int 83:373–378. (PMID: 1999664110.1159/000251174)
Curigliano G, Lenihan D, Fradley M et al (2020) Management of cardiac disease in cancer patients throughout oncological treatment: ESMO consensus recommendations. Ann Oncol 31:171–190. (PMID: 3195933510.1016/j.annonc.2019.10.023) - Contributed Indexing: Keywords: Androgen deprivation therapy; Cardiovascular morbidity; Gonadotropin-releasing hormone-Agonist; Gonadotropin-releasing hormone-Antagonist; Prostate neoplasms
Local Abstract: [Publisher, German] Das Prostatakarzinom ist die häufigste Tumorerkrankung bei Männern. Es sind insbesondere Männer im fortgeschrittenen Alter mit einer erhöhten Prävalenz für das metabolische Syndrom und kardiovaskuläre Erkrankungen betroffen. Die Androgendeprivationstherapie (ADT) ist seit Jahrzehnten die Standardtherapie in verschiedenen Prostatakarzinomstadien und erhöht zusätzlich das Risiko für kardiovaskuläre Erkrankungen und für das metabolische Syndrom. Aus diesen Gründen sollte vor der Initiierung einer ADT ein Screening auf das Vorhandensein von kardiovaskulären Risikofaktoren sowie ggf. eine kardiologische Vorstellung und Mitbetreuung während und nach Abschluss der ADT erfolgen. Darüber hinaus kann bei Patienten mit kardiovaskulären Vorerkrankungen der Einsatz eines GnRH-Antagonisten („gonadotropin-releasing hormone“) helfen, das kardiovaskuläre Risiko zu reduzieren. - Accession Number: 0 (Androgen Antagonists)
0 (Androgens)
33515-09-2 (Gonadotropin-Releasing Hormone) - Publication Date: Date Created: 20231024 Date Completed: 20240307 Latest Revision: 20240307
- Publication Date: 20240307
- Accession Number: 10.1007/s00120-023-02222-1
- Accession Number: 37874334
- Transliterated Title:
Contact CCPL
Copyright 2022 Charleston County Public Library Powered By EBSCO Stacks 3.3.0 [350.3] | Staff Login
No Comments.