Right ventricular global strain in patients with hypertrophic cardiomyopathy with and without right ventricular hypertrophy.

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  • Additional Information
    • Source:
      Publisher: Elsevier Science Ireland Ltd Country of Publication: Ireland NLM ID: 8106411 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7727 (Electronic) Linking ISSN: 0720048X NLM ISO Abbreviation: Eur J Radiol Subsets: MEDLINE
    • Publication Information:
      Publication: Limerick : Elsevier Science Ireland Ltd
      Original Publication: Stuttgart ; New York : Thieme, [c1981-
    • Subject Terms:
      Hypertrophy, Right Ventricular* ; Cardiomyopathy, Hypertrophic*/complications ; Cardiomyopathy, Hypertrophic*/diagnostic imaging; Humans ; Retrospective Studies ; Heart Ventricles/diagnostic imaging ; Reproducibility of Results ; Prognosis ; Stroke Volume
    • Abstract:
      Purpose: Regardless of whether there are morphological abnormalities of right ventricle in hypertrophic cardiomyopathy (HCM) patients, the exact contribution of right ventricular (RV) global strains remains unresolved. We aimed to study the prognostic value of RV global strains in HCM patients with and without RV hypertrophy (RVH).
      Method: A total of 358 HCM patients who underwent the CMR examination and carried out the follow-up were finally included in this retrospective study. The endpoint was a composite of all-cause mortality, aborted SCD, and heart failure readmission. RV hypertrophy (RVH) was defined as maximal RVWT ≥ 5 mm at end-diastole. RV global strains (RV global longitudinal strain (GLS) and RV global circumferential strain (GCS) were measured in HCM patients by cardiac MRI feature tracking technique. The intraobserver and interobserver reproducibility were evaluated. Receiver-operating characteristic curves and Kaplan-Meier curves, cox proportional hazards regression, Likelihood ratio test and Integrated Discrimination Improvement (IDI) analysis were performed. P-value were corrected for multiple testing when using many covariables by a false discovery rate adjustment.
      Results: Over a median follow-up of 25 (range 3-54) months, 49 patients reached the composite endpoints. HCM patients were divided into the RVH group and non-RVH groups. In the multivariate cox proportional hazards regression, after adjusting multiple clinical and imaging variables, RV GLS and RV GCS were independently associated with the composite endpoints in the RVH group (HR: 1.123; 95 % CI: 1.048-1.205; P = 0.002) and non-RVH group (HR: 1.174; 95 % CI: 1.031-1.337; P = 0.015), respectively. And The IDI index of models improved when adding RV GLS (IDI = 0.030, p < 0.001) and RV GLS (IDI = 0.056, p = 0.020), respectively.
      Conclusions: RV GLS and RV GCS are independent predictors of HCM with RVH and without RVH, respectively. RV GLS in the RVH group and RV GCS in the non-RVH group provide additional values for predicting the risk of adverse events.
      Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
      (Copyright © 2023 Elsevier B.V. All rights reserved.)
    • Contributed Indexing:
      Keywords: Cardiac magnetic resonance feature tracking; Hypertrophic Cardiomyopathy; Right ventricular hypertrophy
    • Publication Date:
      Date Created: 20231023 Date Completed: 20231129 Latest Revision: 20240122
    • Publication Date:
      20240122
    • Accession Number:
      10.1016/j.ejrad.2023.111148
    • Accession Number:
      37871355