Effect of Porphyra haitanensis polyphenols from different harvest periods on hypoglycaemic activity based on in vitro digestion and widely targeted metabolomic analysis.

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  • Additional Information
    • Source:
      Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE
    • Publication Information:
      Publication: Barking : Elsevier Applied Science Publishers
      Original Publication: Barking, Eng., Applied Science Publishers.
    • Subject Terms:
      Porphyra*/metabolism ; Diabetes Mellitus, Type 2*; Humans ; Polyphenols/pharmacology ; Polyphenols/metabolism ; Hypoglycemic Agents/pharmacology ; alpha-Glucosidases ; Phenols/pharmacology ; Antioxidants ; Digestion
    • Abstract:
      The hypoglycemic effect of Porphyra is well known. Based on in vitro digestion and metabolomics, the bioaccessibility, antidiabetic activity and phenolic conversion of P. haitanensis were investigated at different harvests. Total polyphenol content (TPC), α-glucosidase inhibition and oxygen radical absorbance capacity (ORAC) increased with harvesting and digestion stages, reaching maximum at the fourth harvest. TPC and α-glucosidase inhibition after digestion reached 130-150 mg/g and 50-90 %, ORAC was 8.7-13.5 times higher than the undigestion. However, bioaccessibility in the first and second harvests was 10-80 % higher than other harvests. The phenolic content in the fourth harvest was up-regulated to 2-30 times than the first and mostly were citrus flavonoids. Redundancy analysis indicated significant correlation between phenolic metabolites and bioactivities in different harvests of P. haitanensis during digestion, with the strongest correlation coefficients were apigenin and genistein. This study provides reference for the application of P. haitanensis in treating type 2 diabetes.
      Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
      (Copyright © 2023 Elsevier Ltd. All rights reserved.)
    • Contributed Indexing:
      Keywords: Diabetes; Harvest period; In vitro simulated digestion; Polyphenols; Porphyra haitanensis; Widely-targeted metabolomic analysis
    • Accession Number:
      0 (Polyphenols)
      0 (Hypoglycemic Agents)
      EC 3.2.1.20 (alpha-Glucosidases)
      0 (Phenols)
      0 (Antioxidants)
    • Publication Date:
      Date Created: 20231022 Date Completed: 20231127 Latest Revision: 20231127
    • Publication Date:
      20250114
    • Accession Number:
      10.1016/j.foodchem.2023.137793
    • Accession Number:
      37866341