A Metabolite Perspective on the Involvement of the Gut Microbiota in Type 2 Diabetes.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, [2000-

Gastrointestinal Microbiome* ; Diabetes Mellitus, Type 2* ; Microbiota*; Animals ; Humans ; Fatty Acids, Volatile ; Diet

Type 2 diabetes (T2D) is a commonly diagnosed condition that has been extensively studied. The composition and activity of gut microbes, as well as the metabolites they produce (such as short-chain fatty acids, lipopolysaccharides, trimethylamine N-oxide, and bile acids) can significantly impact diabetes development. Treatment options, including medication, can enhance the gut microbiome and its metabolites, and even reverse intestinal epithelial dysfunction. Both animal and human studies have demonstrated the role of microbiota metabolites in influencing diabetes, as well as their complex chemical interactions with signaling molecules. This article focuses on the importance of microbiota metabolites in type 2 diabetes and provides an overview of various pharmacological and dietary components that can serve as therapeutic tools for reducing the risk of developing diabetes. A deeper understanding of the link between gut microbial metabolites and T2D will enhance our knowledge of the disease and may offer new treatment approaches. Although many animal studies have investigated the palliative and attenuating effects of gut microbial metabolites on T2D, few have established a complete cure. Therefore, conducting more systematic studies in the future is necessary.

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2021JJ30008, 2020NK2004, 2019TP2004 Hunan Provincial Science and Technology Department; SYL201802003 Double first-class construction project of Hunan Agricultural University; CX20210654 Postgraduate Scientific Research Innovation Project of Hunan Province; 2021RC1004 Science and Technology Innovation and Entrepreneurship Project for University Students of Hunan Province

Keywords: bile acids; dietary diet; gut microbiota; metabolites; short-chain fatty acids

0 (Fatty Acids, Volatile)

Date Created: 20231014 Date Completed: 20231023 Latest Revision: 20231023

20240829

PMC10573635

10.3390/ijms241914991

37834439