Modelling DTPA therapy following Am contamination in rats.

Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0415677 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-2099 (Electronic) Linking ISSN: 0301634X NLM ISO Abbreviation: Radiat Environ Biophys Subsets: MEDLINE

Original Publication: Berlin, New York, Springer-Verlag.

Pentetic Acid*/therapeutic use ; Plutonium*; Humans ; Rats ; Animals ; Americium ; Models, Biological ; Chelating Agents/therapeutic use

A major challenge in modelling the decorporation of actinides (An), such as americium (Am), with DTPA (diethylenetriaminepentaacetic acid) is the fact that standard biokinetic models become inadequate for assessing radionuclide intake and estimating the resulting dose, as DTPA perturbs the regular biokinetics of the radionuclide. At present, most attempts existing in the literature are empirical and developed mainly for the interpretation of one or a limited number of specific incorporation cases. Recently, several approaches have been presented with the aim of developing a generic model, one of which reported the unperturbed biokinetics of plutonium (Pu), the chelation process and the behaviour of the chelated compound An-DTPA with a single model structure. The aim of the approach described in this present work is the development of a generic model that is able to describe the biokinetics of Am, DTPA and the chelate Am-DTPA simultaneously. Since accidental intakes in humans present many unknowns and large uncertainties, data from controlled studies in animals were used. In these studies, different amounts of DTPA were administered at different times after contamination with known quantities of Am. To account for the enhancement of faecal excretion and reduction in liver retention, DTPA is assumed to chelate Am not only in extracellular fluids, but also in hepatocytes. A good agreement was found between the predictions of the proposed model and the experimental results for urinary and faecal excretion and accumulation and retention in the liver. However, the decorporation from the skeletal compartment could not be reproduced satisfactorily under these simple assumptions.
(© 2023. The Author(s).)

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Keywords: Americium; Biokinetic model; Chelation; DTPA; Decorporation

7A314HQM0I (Pentetic Acid)
VW92PHU2UY (Americium)
0 (Chelating Agents)
53023GN24M (Plutonium)

Date Created: 20231013 Date Completed: 20231108 Latest Revision: 20231201

20231215

PMC10628027

10.1007/s00411-023-01046-z

37831188