Fatty Acids and their Proteins in Adipose Tissue Inflammation.

Publisher: Humana Press Country of Publication: United States NLM ID: 9701934 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0283 (Electronic) Linking ISSN: 10859195 NLM ISO Abbreviation: Cell Biochem Biophys Subsets: MEDLINE

Original Publication: Totowa, NJ : Humana Press, c1996-

Fatty Acids*/metabolism ; Adipose Tissue*; Humans ; Adipocytes ; Inflammation/metabolism ; Lipid Droplet Associated Proteins/metabolism

Chronic low-grade adipose tissue inflammation is associated with metabolic disorders. Inflammation results from the intertwined cross-talks of pro-inflammatory and anti-inflammatory pathways in the immune response of adipose tissue. In addition, adipose FABP4 levels and lipid droplet proteins are involved in systemic and tissue inflammation. Dysregulated adipocytes help infiltrate immune cells derived from bone marrow responsible for producing cytokines and chemokines. When adipose tissue expands in excess, adipocyte exhibits increased secretion of adipokines and is implicated in metabolic disturbances due to the release of free fatty acids. This review presents an emerging concept in adipose tissue fat metabolism, fatty acid handling and binding proteins, and lipid droplet proteins and their involvement in inflammatory disorders.
(© 2023. The Author(s).)

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Keywords: Dietary fats; Inflammation; LCPUFA; Metabolic syndrome; Obesity; n-3 PUFA

0 (Fatty Acids)
0 (Lipid Droplet Associated Proteins)

Date Created: 20231004 Date Completed: 20240216 Latest Revision: 20240217

20240217

PMC10867084

10.1007/s12013-023-01185-6

37794302