Randomised controlled trial of preconception lifestyle intervention on maternal and offspring health in people with increased risk of gestational diabetes: study protocol for the BEFORE THE BEGINNING trial.

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  • Additional Information
    • Source:
      Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE
    • Publication Information:
      Original Publication: [London] : BMJ Publishing Group Ltd, 2011-
    • Subject Terms:
      Diabetes, Gestational*/prevention & control ; Diabetes Mellitus, Type 2*/prevention & control ; Cardiovascular Diseases*; Pregnancy ; Female ; Child ; Humans ; Adolescent ; Young Adult ; Adult ; Life Style ; Glucose ; Randomized Controlled Trials as Topic
    • Abstract:
      Introduction: Gestational diabetes mellitus (GDM) is associated with increased risk for type 2 diabetes in the mother and cardiometabolic diseases in the child. The preconception period is an optimal window to adapt the lifestyle for improved outcomes for both mother and child. Our aim is to determine the effect of a lifestyle intervention, initiated before and continued throughout pregnancy, on maternal glucose tolerance and other maternal and infant cardiometabolic outcomes.
      Methods and Analysis: This ongoing randomised controlled trial has included 167 females aged 18-39 years old at increased risk for GDM who are contemplating pregnancy. The participants were randomly allocated 1:1 to an intervention or control group. The intervention consists of exercise (volume is set by a heart rate-based app and corresponds to ≥ 1 hour of weekly exercise at ≥ 80% of individual heart rate maximum), and time-restricted eating (≤ 10 hours/day window of energy intake). The primary outcome measure is glucose tolerance in gestational week 28. Maternal and offspring outcomes are measured before and during pregnancy, at delivery, and at 6-8 weeks post partum. Primary and secondary continuous outcome measures will be compared between groups based on the 'intention to treat' principle using linear mixed models.
      Ethics and Dissemination: The Regional Committees for Medical and Health Research Ethics in Norway has approved the study (REK 143756). The anonymised results will be submitted for publication and posted in a publicly accessible database of clinical study results.
      Trial Registration Number: Clinical trial gov NCT04585581.
      Competing Interests: Competing interests: None declared.
      (© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
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    • Contributed Indexing:
      Keywords: clinical trial; diabetes in pregnancy; fetal medicine; maternal medicine; nutrition & dietetics; obesity
    • Molecular Sequence:
      ClinicalTrials.gov NCT04585581
    • Accession Number:
      IY9XDZ35W2 (Glucose)
    • Publication Date:
      Date Created: 20231004 Date Completed: 20231006 Latest Revision: 20231007
    • Publication Date:
      20231215
    • Accession Number:
      PMC10551988
    • Accession Number:
      10.1136/bmjopen-2023-073572
    • Accession Number:
      37793933