Frenolicins H and I from the caterpillar-associated Streptomyces sp. TBRC17107.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Additional Information
    • Source:
      Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE
    • Publication Information:
      Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003-
    • Subject Terms:
      Streptomyces*/chemistry ; Microbial Sensitivity Tests* ; Plasmodium falciparum*/drug effects ; Staphylococcus aureus*/drug effects ; Anti-Bacterial Agents*/pharmacology ; Anti-Bacterial Agents*/chemistry; Animals ; Molecular Structure ; Anthraquinones/pharmacology ; Anthraquinones/chemistry ; Anthraquinones/isolation & purification ; Humans ; Bacillus cereus/drug effects ; Antimalarials/pharmacology ; Antimalarials/chemistry ; Alternaria/drug effects ; Antifungal Agents/pharmacology ; Antifungal Agents/chemistry
    • Abstract:
      Two undescribed frenolicins H and I ( 1 and 2 ) along with six previously described frenolicin analogues [frenolicins A ( 3 ), B ( 4 ), UCF76-B ( 5 ), E - G ( 6 - 8 )] and two anthraquinones [3,8-dihydroxy-1-propylanthraquinone-2-carboxylic acid ( 9 ) and 3,8-dihydroxy-1-propylanthraquinone ( 10 )] were isolated from a longkong bark eating caterpillar-derived Streptomyces sp. TBRC17107. The chemical structures were determined by NMR spectroscopic information and HRESIMS data. Frenolicins H ( 1 ) and I ( 2 ) showed weak cytotoxicity against malignant and non-malignant cells. Frenolicins A ( 3 ) and B ( 4 ) showed antimalarial activity against Plasmodium falciparum (IC 50 17.4 and 1.37  μ M), antibacterial activity against Bacillus cereus and Staphylococcus aureus (MIC 50.0 and 0.20  μ g/mL). Only frenolicin B had anti-plant pathogenic fungal activity against Collectotrichum acutatum and Alternaria brassicicola with MIC values of MIC 1.56 and 6.25  μ g/mL, respectively. Frenolicins A and G possessed anti- Mycobacterium tuberculosis with equal MICs of 25.0  μ g/mL.
    • Contributed Indexing:
      Keywords: Insect-derived actinomycete; Streptomyces; anthraquinone; antibiotics; frenolicin
    • Accession Number:
      0 (Anti-Bacterial Agents)
      0 (Anthraquinones)
      0 (Antimalarials)
      0 (Antifungal Agents)
    • Publication Date:
      Date Created: 20231004 Date Completed: 20241009 Latest Revision: 20241009
    • Publication Date:
      20241009
    • Accession Number:
      10.1080/14786419.2023.2263902
    • Accession Number:
      37791589