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Miss Jane's Building (Edisto Library Temporary Location)
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4D Printable Salicylic Acid Photopolymers for Sustained Drug Releasing, Shape Memory, Soft Tissue Scaffolds.
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- Author(s): King O;King O; Pérez-Madrigal MM; Pérez-Madrigal MM; Pérez-Madrigal MM; Pérez-Madrigal MM; Murphy ER; Murphy ER; Murphy ER; Murphy ER; Hmayed AAR; Hmayed AAR; Dove AP; Dove AP; Weems AC; Weems AC; Weems AC; Weems AC; Weems AC
- Source:
Biomacromolecules [Biomacromolecules] 2023 Nov 13; Vol. 24 (11), pp. 4680-4694. Date of Electronic Publication: 2023 Sep 25.- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't- Language:
English - Source:
- Additional Information
- Source: Publisher: American Chemical Society Country of Publication: United States NLM ID: 100892849 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1526-4602 (Electronic) Linking ISSN: 15257797 NLM ISO Abbreviation: Biomacromolecules Subsets: MEDLINE
- Publication Information: Original Publication: Washington, DC : American Chemical Society, c2000-
- Subject Terms:
- Abstract: 3D printing of pharmaceuticals offers a unique opportunity for long-term, sustained drug release profiles for an array of treatment options. Unfortunately, this approach is often limited by physical compounding or processing limitations. Modification of the active drug into a prodrug compound allows for seamless incorporation with advanced manufacturing methods that open the door to production of complex tissue scaffold drug depots. Here we demonstrate this concept using salicylic acids with varied prodrug structures for control of physical and chemical properties. The role of different salicylic acid derivatives (salicylic acid, bromosalicylic allyl ester, iodosalicylic allyl ester) and linker species (allyl salicylate, allyl 2-(allyloxy)benzoate, allyl 2-(((allyloxy)carbonyl)oxy)benzoate) were investigated using thiol-ene cross-linking in digital light processing (DLP) 3D printing to produce porous prodrug tissue scaffolds containing more than 50% salicylic acid by mass. Salicylic acid photopolymer resins were all found to be highly reactive (solidification within 5 s of irradiation at λ = 405 nm), while the cross-linked solids display tunable thermomechanical behaviors with low glass transition temperatures ( T
g s) and elastomeric behaviors, with the carbonate species displaying an elastic modulus matching that of adipose tissue (approximately 65 kPa). Drug release profiles were found to be zero order, sustained release based upon hydrolytic degradation of multilayered scaffolds incorporating fluorescent modeling compounds, with release rates tuned through selection of the linker species. Cytocompatibility in 2D and 3D was further demonstrated for all species compared to polycarbonate controls, as well as salicylic acid-containing composites (physical incorporation), over a 2-week period using murine fibroblasts. The use of drugs as the matrix material for solid prodrug tissue scaffolds opens the door to novel therapeutic strategies, longer sustained release profiles, and even reduced complications for advanced medicine. - Accession Number: O414PZ4LPZ (Salicylic Acid)
0 (Delayed-Action Preparations)
0 (Prodrugs)
0 (Esters) - Publication Date: Date Created: 20230925 Date Completed: 20231114 Latest Revision: 20231122
- Publication Date: 20231215
- Accession Number: 10.1021/acs.biomac.3c00416
- Accession Number: 37747816
- Source:
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