Cordycepin, a bioactive compound from Cordyceps spp ., moderates Alzheimer's disease-associated pathology via anti-oxidative stress and autophagy activation.

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  • Additional Information
    • Source:
      Publisher: Informa Healthcare Country of Publication: England NLM ID: 100888334 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-2213 (Electronic) Linking ISSN: 10286020 NLM ISO Abbreviation: J Asian Nat Prod Res Subsets: MEDLINE
    • Publication Information:
      Publication: London : Informa Healthcare
      Original Publication: [Newark, N.J.?] : Harwood Academic Publishers,
    • Subject Terms:
      Alzheimer Disease*/drug therapy ; Deoxyadenosines*/pharmacology ; Oxidative Stress*/drug effects ; Autophagy*/drug effects ; Cordyceps*/chemistry ; Membrane Proteins*; Humans ; Molecular Structure ; Amyloid beta-Protein Precursor/metabolism ; Sirtuin 1/metabolism ; Sirtuin 1/drug effects ; Cell Line, Tumor ; ADAM10 Protein/metabolism ; Cell Proliferation/drug effects ; Amyloid Precursor Protein Secretases/metabolism
    • Abstract:
      Alzheimer's causes cognitive dysfunction. This study investigated the neuro-promoting effects of cordycepin on amyloid-beta precursor protein (APP) synthesis in human neuroblastoma SH-SY5Y cells. Cordycepin was found to boost SH-SY5Y cell proliferation and decreased AD pathology. APP, PS1, and PS2 were downregulated whereas ADAM10 and SIRT1 were upregulated by cordycepin. Cordycepin also reduced APP secretion in a dose-dependent manner. Cordycepin alleviated oxidative stress by the upregulation of GPX and SOD , as well as autophagy genes ( LC3 , ATG5 , and ATG12 ). Cordycepin activity was also found to be SIRT1-dependent. Therefore, cordycepin may relieve the neuronal degeneration caused by APP overproduction, and oxidative stress.
    • Contributed Indexing:
      Keywords: Alzheimer’s disease; Cordycepin; SIRT1; autophagy; oxidative stress
    • Accession Number:
      0 (Deoxyadenosines)
      GZ8VF4M2J8 (cordycepin)
      0 (Amyloid beta-Protein Precursor)
      EC 3.5.1.- (Sirtuin 1)
      EC 3.4.24.81 (ADAM10 Protein)
      EC 3.4.24.81 (ADAM10 protein, human)
      EC 3.4.- (Amyloid Precursor Protein Secretases)
      EC 3.5.1.- (SIRT1 protein, human)
      0 (Membrane Proteins)
    • Publication Date:
      Date Created: 20230922 Date Completed: 20240503 Latest Revision: 20240503
    • Publication Date:
      20240503
    • Accession Number:
      10.1080/10286020.2023.2258797
    • Accession Number:
      37735930